Simple Summary The purinergic P2X7 receptor (P2X7R) is a cell membrane protein whose
activation has been related to a variety of cellular processes, while its dysregulation has …

Cancer metastasis is one of the leading causes of death worldwide, motivating research into
identifying new methods of preventing cancer metastasis. Recently there has been …

Transient receptor potential vanilloid 4 (TRPV4) is a calcium-permeable cation channel that
has been associated with several types of cancer. However, its biological significance, as …

Tumor growth and metastatic spreading are heavily affected by the P2X7 receptor as well as
microvesicles and exosomes release into the tumor microenvironment. P2X7 receptor …

Biophysical cues from the cellular microenvironment are detected by mechanosensitive
machineries that translate physical signals into biochemical signaling cascades. At the …

Hepatocellular carcinoma (HCC) is a malignant tumor, frequently causing both intrahepatic
and extrahepatic metastases. The overall prognosis of patients with metastatic HCC is poor …

Cells utilize calcium channels as one of the main signaling mechanisms to sense changes
in the extracellular space and convert these changes to intracellular signals. Calcium …

TRAIL specifically induces apoptosis in cancer cells without affecting healthy cells. However,
TRAIL's cancer cytotoxicity was insufficient in clinical trials. Circulatory-shear stress is known …

Maintaining the clarity of the cornea is essential for vision, and is achieved through an
exquisite array of collagen fibrils and proteoglycans in the corneal stroma. Alterations in the …

Cancer cells proliferate, differentiate and migrate by repurposing physiological signalling
mechanisms. In particular, altered calcium signalling is emerging as one of the most …