During bone formation, collagen fibrils mineralize with carbonated hydroxyapatite, leading to
a hybrid material with excellent properties. Other minerals are also known to nucleate within …

In bone, structural components such as mineral extend across length scales to provide
essential biomechanical functions. Using X-ray micro-computed tomography (µCT), and …

Metabolic abnormalities, such as diabetes mellitus and obesity, can impact bone quantity
and/or bone quality. In this work, we characterize bone material properties, in terms of …

Collagen fibrils present periodic structures, which provide space for intrafibrillar growth of
oriented hydroxyapatite nanocrystals in bone and contribute to the good mechanical …

Skeletal adaptation is substantially influenced by mechanical loads. Osteocytes and their
lacuno-canalicular network have been identified as a key player in load sensation and bone …

Background Bone turnover balance favors bone formation, especially mineralization, during
the first 3 years of treatment with TNF-α inhibitors (TNFi). Our aim was to evaluate the course …

Glucocorticoid (or steroid) induced osteoporosis (GIOP) is the leading form of secondary
osteoporosis, affecting up to 50% of patients receiving chronic glucocorticoid therapy. Bone …

The high occurrence of distal fibula fractures among older women suggests a potential link
to impaired bone health. Here we used a multiscale imaging approach to investigate the …

Bone becomes more fragile with ageing. Among many structural changes, a thin layer of
highly mineralized and brittle tissue covers part of the external surface of the thin femoral …

Bone metastases are the most severe and prevalent consequences of prostate cancer (PC),
affecting more than 80% of patients with advanced PC. PCBMs generate pain, pathological …