Unveiling the future of metabolic medicine: omics technologies driving personalized solutions for precision treatment of metabolic disorders
Metabolic disorders are increasingly prevalent worldwide, leading to high rates of morbidity
and mortality. The variety of metabolic illnesses can be addressed through personalized …
and mortality. The variety of metabolic illnesses can be addressed through personalized …
The role of pathogens in diabetes pathogenesis and the potential of immunoproteomics as a diagnostic and prognostic tool
MU Sohail, F Mashood, A Oberbach… - Frontiers in …, 2022 - frontiersin.org
Diabetes mellitus (DM) is a group of metabolic diseases marked by hyperglycemia, which
increases the risk of systemic infections. DM patients are at greater risk of hospitalization …
increases the risk of systemic infections. DM patients are at greater risk of hospitalization …
[HTML][HTML] Plasma proteins and onset of type 2 diabetes and diabetic complications: Proteome-wide Mendelian randomization and colocalization analyses
We conduct proteome-wide Mendelian randomization and colocalization analyses to
decipher the associations of blood proteins with the risk of type 2 diabetes and diabetic …
decipher the associations of blood proteins with the risk of type 2 diabetes and diabetic …
Epigenetic scores for the circulating proteome as tools for disease prediction
Protein biomarkers have been identified across many age-related morbidities. However,
characterising epigenetic influences could further inform disease predictions. Here, we …
characterising epigenetic influences could further inform disease predictions. Here, we …
A proteomic survival predictor for COVID-19 patients in intensive care
V Demichev, P Tober-Lau, T Nazarenko… - PLOS Digital …, 2022 - journals.plos.org
Global healthcare systems are challenged by the COVID-19 pandemic. There is a need to
optimize allocation of treatment and resources in intensive care, as clinically established risk …
optimize allocation of treatment and resources in intensive care, as clinically established risk …
Associations of plasma proteomics with type 2 diabetes and related traits: results from the longitudinal KORA S4/F4/FF4 Study
Aims/hypothesis This study aimed to elucidate the aetiological role of plasma proteins in
glucose metabolism and type 2 diabetes development. Methods We measured 233 proteins …
glucose metabolism and type 2 diabetes development. Methods We measured 233 proteins …
A Guide for Selection of Genetic Instruments in Mendelian Randomization Studies of Type 2 Diabetes and HbA1c: Toward an Integrated Approach
In this study we examine the instrument selection strategies currently used throughout the
type 2 diabetes and HbA1c Mendelian randomization (MR) literature. We then argue for a …
type 2 diabetes and HbA1c Mendelian randomization (MR) literature. We then argue for a …
Plasma proteomics of renal function: a transethnic meta-analysis and mendelian randomization study
PR Matías-García, R Wilson, Q Guo… - Journal of the …, 2021 - journals.lww.com
Background Studies on the relationship between renal function and the human plasma
proteome have identified several potential biomarkers. However, investigations have been …
proteome have identified several potential biomarkers. However, investigations have been …
Metabolic syndrome and the plasma proteome: from association to causation
Abstract Background The metabolic syndrome (MetS), defined by the simultaneous
clustering of cardio-metabolic risk factors, is a significant worldwide public health burden …
clustering of cardio-metabolic risk factors, is a significant worldwide public health burden …
Proteomic predictors of incident diabetes: results from the atherosclerosis risk in communities (ARIC) study
OBJECTIVE The plasma proteome preceding diabetes can improve our understanding of
diabetes pathogenesis. RESEARCH DESIGN AND METHODS In 8,923 Atherosclerosis Risk …
diabetes pathogenesis. RESEARCH DESIGN AND METHODS In 8,923 Atherosclerosis Risk …