Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide, and fatty acid
metabolism has been well studied. Short-chain fatty acids (SCFAs) have been less …

Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide.
Metabolic dysfunction is a fundamental core mechanism underlying CVDs. Previous studies …

Heart failure (HF) has become a worldwide public health problem that seriously threatens
human's health. Due to" multi-target" effect, traditional Chinese medicine (TCM) has unique …

Peroxisome proliferator-activated receptors (PPARs), members of the nuclear receptor
superfamily, are important in whole-body energy metabolism. PPARs are classified into …

Heart failure (HF) patients often suffer from multiple comorbidities, such as diabetes, atrial
fibrillation, depression, chronic obstructive pulmonary disease, and chronic kidney disease …

The main hallmark of myocardial substrate metabolism in cardiac hypertrophy or heart
failure is a shift from fatty acid oxidation to greater reliance on glycolysis. However, the close …

Heart failure (HF) is associated with metabolic perturbations, particularly of fatty acids (FAs),
which remain to be better understood in humans. This study aimed at testing the hypothesis …

The use of poly (lactic-co-glycolic acid)(PLGA)-based nanocarriers presents several major
challenges, including their synthetic hydrophobic surface, low transfection efficiency, short …

In heart failure (HF), energy metabolism pathway in cardiac muscle changes from fatty acid β-
oxidation to glycolysis. However, the exact mechanism is unknown. Sarcoendoplasmic …

Fatty acids beyond their role as an endogenous energy source and storage are increasingly
considered as signaling molecules regulating various physiological effects in metabolism …