The extracellular matrix (ECM) is a ubiquitous member of the body and is key to the
maintenance of tissue and organ integrity. Initially thought to be a bystander in many cellular …

Cutaneous neurogenic inflammation (CNI) is inflammation that is induced (or enhanced) in
the skin by the release of neuropeptides from sensory nerve endings. Clinical manifestations …

We investigated the dynamics of the gene expression of M1 and M2 macrophage markers
during skin wound healing in mice. Expression of M1-macrophage markers, such as Il12a …

The pathogenesis of hypertrophic scar (HS) is still poorly understood. Macrophages,
especially the polarisation of that to M1 or M2, play a pivotal role in control of the degree of …

Although the inflammatory and proliferative phases of wound healing have been well
described, much less is known about how healing resolves. During the resolution phase …

Chronic itch with an itch–scratch vicious circle is a significant problem in a large amount of
diseases. Some of these diseases, such as psoriasis, atopic dermatitis, prurigo nodularis …

Skin barrier defects play an important role in atopic dermatitis (AD) pathogenesis. Loricrin,
an important barrier protein suppressed in human AD, is down-regulated by IL-4 in …

Keratinocytes are actively implicated in the physiopathology of atopic dermatitis (AD), a skin
allergy condition widely distributed worldwide. Glycomacropeptide (GMP) is a milk-derived …

Healing of skin wounds is orchestrated by various types of immune cells, but little is known
about the role of FoxP3+ regulatory T cells (Tregs) in this process. Here, we determined if …

Atopic Dermatitis (AD) skin is susceptible to Staphylococcus aureus (SA) infection,
potentially exposing it to a plethora of toxins and virulent determinants, including Panton …