Matrix metalloproteinase-9 (MMP-9) and its inhibitors in cancer: A minireview
Matrix metalloproteinases (MMPs) are zinc dependent proteolytic metalloenzyme. MMP-9 is
one of the most complex forms of matrix metalloproteinases. MMP-9 has the ability to …
one of the most complex forms of matrix metalloproteinases. MMP-9 has the ability to …
Two decades of recent advances of Ugi reactions: synthetic and pharmaceutical applications
Multicomponent reactions (MCRs) are powerful synthetic tools in which more than two
starting materials couple with each other to form multi-functionalized compounds in a one …
starting materials couple with each other to form multi-functionalized compounds in a one …
Novel matrix metalloproteinase-9 (MMP-9) inhibitors in cancer treatment
ZA Rashid, SK Bardaweel - International journal of molecular sciences, 2023 - mdpi.com
Matrix metalloproteinases (MMPs) belong to a family of zinc-dependent proteolytic
metalloenzymes. MMP-9, a member of the gelatinase B family, is characterized as one of the …
metalloenzymes. MMP-9, a member of the gelatinase B family, is characterized as one of the …
Molecular hybridization design and synthesis of novel spirooxindole-based MDM2 inhibitors endowed with BCL2 signaling attenuation; a step towards the next …
G Lotfy, YMA Aziz, MM Said, H El Sayed, H El Sayed… - Bioorganic …, 2021 - Elsevier
Despite the achieved progress in developing efficient MDM2-p53 protein-protein interaction
inhibitors (MDM2 inhibitors), the acquired resistance of tumor cells to such p53 activators …
inhibitors (MDM2 inhibitors), the acquired resistance of tumor cells to such p53 activators …
Targeting the interplay between MMP-2, CA II and VEGFR-2 via new sulfonamide-tethered isomeric triazole hybrids; Microwave-assisted synthesis, computational …
Recently, the interest in targeting metalloenzymes is obviously growing for halting various
tumor progression events and surmounting the resistance due to routine chemotherapy …
tumor progression events and surmounting the resistance due to routine chemotherapy …
Design and synthesis of new bis (1, 2, 4-triazolo [3, 4-b][1, 3, 4] thiadiazines) and bis ((quinoxalin-2-yl) phenoxy) alkanes as anti-breast cancer agents through dual …
A number of new 1, ω-bis ((acetylphenoxy) acetamide) alkanes 5a–f were prepared then
their bromination using NBS furnished the novel bis (2-bromoacetyl) phenoxy) acetamides …
their bromination using NBS furnished the novel bis (2-bromoacetyl) phenoxy) acetamides …
Two decades of recent advances of Passerini reactions: synthetic and potential pharmaceutical applications
Passerini three-component reactions (P-3CRs) based on isonitriles are impressive synthetic
protocols in which a number of starting materials react with each other to provide poly …
protocols in which a number of starting materials react with each other to provide poly …
Structure-based design and optimization of pyrimidine-and 1, 2, 4-triazolo [4, 3-a] pyrimidine-based matrix metalloproteinase-10/13 inhibitors via Dimroth …
LF Awad, M Teleb, NA Ibrahim, MM Abu-Serie… - Bioorganic …, 2020 - Elsevier
Recently, interest in matrix metalloproteinases (MMPs)-10 and-13 has been revitalized with
the growing knowledge on their relevance within the MMPs network and significance of their …
the growing knowledge on their relevance within the MMPs network and significance of their …
Reinvestigation of Passerini and Ugi scaffolds as multistep apoptotic inducers via dual modulation of caspase 3/7 and P53-MDM2 signaling for halting breast cancer
Selective induction of breast cancer apoptosis is viewed as the mainstay of various ongoing
oncology drug discovery programs. Passerini scaffolds have been recently exploited as …
oncology drug discovery programs. Passerini scaffolds have been recently exploited as …
Battling colorectal cancer via s-triazine-based MMP-10/13 inhibitors armed with electrophilic warheads for concomitant ferroptosis induction; the first-in-class dual …
CA Morcos, SN Khattab, NS Haiba, RW Bassily… - Bioorganic …, 2023 - Elsevier
There is an increasing interest in halting CRC by combining ferroptosis with other forms of
tumor cell death. However, ferroptosis induction is seldom studied in tandem with inhibiting …
tumor cell death. However, ferroptosis induction is seldom studied in tandem with inhibiting …