MicroRNAs (miRNAs) are critical regulators of gene expression. As miRNAs are frequently
deregulated in many human diseases, including cancer and immunological disorders, it is …

The discovery of the first microRNA (miRNA) over 20 years ago has ushered in a new era in
molecular biology. There are now over 2000 miRNAs that have been discovered in humans …

MicroRNAs (miRNAs) are small non-coding RNAs that function as guide molecules in RNA
silencing. Targeting most protein-coding transcripts, miRNAs are involved in nearly all …

Small-RNA-guided gene regulation has emerged as one of the fundamental principles in
cell function, and the major protein players in this process are members of the Argonaute …

Non-coding RNAs generally form ribonucleoprotein (RNP) complexes with their partner
proteins to exert their functions. Small RNAs, including microRNAs, small interfering RNAs …

Since its relatively recent discovery, RNA interference (RNAi) has emerged as a potent,
specific and ubiquitous means of gene regulation. Through a number of pathways that are …

RNAi is widely appreciated as a powerful regulator of mRNA translation in the cytoplasm of
mammalian cells. However, the presence and activity of RNAi factors in the mammalian …

Small RNAs directly or indirectly impact nearly every biological process in eukaryotic cells.
To perform their myriad roles, not only must precise small RNA species be generated, but …

It is well established that 20-to 30-nt small RNAs, including small interfering RNAs,
microRNAs and Piwi-interacting RNAs, play crucial roles in regulating gene expression and …

Small silencing RNAs—small interfering RNAs (siRNAs) or microRNAs (miRNAs)—direct
posttranscriptional gene silencing of their mRNA targets as guides for the RNA-induced …