Aldehyde toxicity and metabolism: the role of aldehyde dehydrogenases in detoxification, drug resistance and carcinogenesis
A Ahmed Laskar, H Younus - Drug metabolism reviews, 2019 - Taylor & Francis
Aldehydes are carbonyl compounds found ubiquitously in the environment, derived from
both natural and anthropogenic sources. As the aldehydes are reactive species, therefore …
both natural and anthropogenic sources. As the aldehydes are reactive species, therefore …
E-cigarette use causes a unique innate immune response in the lung, involving increased neutrophilic activation and altered mucin secretion
B Reidel, G Radicioni, PW Clapp, AA Ford… - American journal of …, 2018 - atsjournals.org
Rationale: E-cigarettes have become increasingly popular and little is known about their
potential adverse health effects. Objectives: To determine the effects of e-cigarette use on …
potential adverse health effects. Objectives: To determine the effects of e-cigarette use on …
Use of airway epithelial cell culture to unravel the pathogenesis and study treatment in obstructive airway diseases
TCJ Mertens, H Karmouty-Quintana, C Taube… - Pulmonary …, 2017 - Elsevier
Asthma and chronic obstructive pulmonary disease (COPD) are considered as two distinct
obstructive diseases. Both chronic diseases share a component of airway epithelial …
obstructive diseases. Both chronic diseases share a component of airway epithelial …
Oxidative and reductive metabolism of lipid-peroxidation derived carbonyls
M Singh, A Kapoor, A Bhatnagar - Chemico-biological interactions, 2015 - Elsevier
Extensive research has shown that increased production of reactive oxygen species (ROS)
results in tissue injury under a variety of pathological conditions and chronic degenerative …
results in tissue injury under a variety of pathological conditions and chronic degenerative …
The nuclear hypoxia-regulated NLUCAT1 long non-coding RNA contributes to an aggressive phenotype in lung adenocarcinoma through regulation of oxidative …
L Moreno Leon, M Gautier, R Allan, M Ilié, N Nottet… - Oncogene, 2019 - nature.com
Lung cancer is the leading cause of cancer death worldwide, with poor prognosis and a high
rate of recurrence despite early surgical removal. Hypoxic regions within tumors represent …
rate of recurrence despite early surgical removal. Hypoxic regions within tumors represent …
Lung transcriptome of a COVID-19 patient and systems biology predictions suggest impaired surfactant production which may be druggable by surfactant therapy
ABMMK Islam, MAAK Khan - Scientific reports, 2020 - nature.com
An incomplete understanding of the molecular mechanisms behind impairment of lung
pathobiology by COVID-19 complicates its clinical management. In this study, we analyzed …
pathobiology by COVID-19 complicates its clinical management. In this study, we analyzed …
m6A RNA methylation regulators could contribute to the occurrence of chronic obstructive pulmonary disease
X Huang, D Lv, X Yang, M Li… - Journal of Cellular and …, 2020 - Wiley Online Library
Abstract N6‐methyladenosine (m6A) RNA methylation, the most prevalent internal chemical
modification of mRNA, has been reported to participate in the progression of various …
modification of mRNA, has been reported to participate in the progression of various …
The customizable e-cigarette resistance influences toxicological outcomes: Lung degeneration, inflammation, and oxidative stress-induced in a rat model
Despite the knowledge gap regarding the risk-benefit ratio of the electronic cigarette (e-cig),
its use has grown exponentially, even in teenagers. E-cig vapor contains carcinogenic …
its use has grown exponentially, even in teenagers. E-cig vapor contains carcinogenic …
Ultrafast gas chromatography coupled to electronic nose to identify volatile biomarkers in exhaled breath from chronic obstructive pulmonary disease patients: a pilot …
M Rodríguez‐Aguilar, S Ramírez‐García… - Biomedical …, 2019 - Wiley Online Library
An analytical method to identify volatile organic compounds (VOCs) in the exhaled breath
from patients with a diagnosis of chronic obstructive pulmonary disease (COPD) using a …
from patients with a diagnosis of chronic obstructive pulmonary disease (COPD) using a …
[HTML][HTML] ALDH3A1 acts as a prognostic biomarker and inhibits the epithelial mesenchymal transition of oral squamous cell carcinoma through IL-6/STAT3 signaling …
Y Qu, Y He, Y Yang, S Li, W An, Z Li, X Wang… - Journal of …, 2020 - ncbi.nlm.nih.gov
Objectives: Aldehyde dehydrogenase 3A1 (ALDH3A1) is a member of the ALDH superfamily
and its relationship with oral squamous cell carcinoma (OSCC) still unknown. In our subject …
and its relationship with oral squamous cell carcinoma (OSCC) still unknown. In our subject …