Abstract The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …

Systemic chronic inflammation (SCI) is persistent, health-damaging, low-grade inflammation
that plays a major role in immunosenescence and in development and progression of many …

Inhalation of silica particles is an environmental and occupational cause of silicosis, a type
of pneumoconiosis. Development of the lung silicosis is a unique process in which the …

Autoinflammatory diseases (AIDs) represent a rare and heterogeneous group of disorders
characterized by recurrent episodes of inflammation and a broad range of clinical …

Inflammasomes are assembled by innate immune sensors that cells employ to detect a
range of danger signals and respond with pro‐inflammatory signalling. Inflammasomes …

Inflammatory bowel disease (IBD) remains a persistent health problem with a global burden
surging over 6.8 million cases currently. Clinical pathology of IBD is complicated; however …

Maintenance of immune homeostasis is an intricate process wherein inflammasomes play a
pivotal role by contributing to innate and adaptive immune responses. Inflammasomes are …

Pyroptosis is a cell death process that causes inflammation and contributes to numerous
diseases. Pyroptosis is mediated by caspase-1 family proteases that cleave the pore …

Pain is a complex problem affecting millions of people worldwide. The current therapies to
reduce pain are limited as many treatment options inadequately address the causes of pain …

In this review, we have summarized classical post-translational modifications (PTMs) such
as phosphorylation, ubiquitylation, and SUMOylation of the different components of one of …