Glycosaminoglycans (GAGs) are complex polysaccharides exhibiting a vast structural
diversity and fulfilling various functions mediated by thousands of interactions in the …

Heparin (HP) and heparan sulfate (HS) are linear, anionically charged polysaccharides well-
known for their diverse biological activities. While HP is generally localized in mast cells and …

Heparan sulfate (HS) has multifaceted biological activities. To date, no libraries of HS
oligosaccharides bearing systematically varied sulfation structures are available owing to …

Fondaparinux, a clinically approved anticoagulant pentasaccharide for the treatment of
thrombotic diseases, displays better efficacy and biosafety than other heparin-based …

Reported herein is a scalable chemical synthesis of disaccharide building blocks for
heparan sulfate (HS) oligosaccharide assembly. The use of d-glucuronate-based acceptors …

Glycosaminoglycans (GAGs) are naturally occurring acidic polysaccharides with wide
applications in pharmaceuticals, cosmetics, and health foods. The diverse biological …

Heparan sulfate (HS) regulates a wide range of biological events, including blood
coagulation, cancer development, cell differentiation, and viral infections. It is generally …

Herein we utilise automated glycan assembly to complete solid-phase synthesis of defined
heparan sulfate oligosaccharides, employing challenging D-glucuronate disaccharide …

Abstract Highly stereoselective synthesis of 1, 2-cis glycosides remains a challenging task
due to the lack of reliable neighboring group participation (NGP) from the 2-O-acyl …

Heparan sulfate (HS), a sulfated linear carbohydrate that decorates the cell surface and
extracellular matrix, is ubiquitously distributed throughout the animal kingdom and …