Microbiota and the immune system—actors in the gastric cancer story

M Majewski, P Mertowska, S Mertowski, K Smolak… - Cancers, 2022 - mdpi.com
Simple Summary Stomach cancer is one of the most commonly diagnosed cancers in the
world. Although the number of new cases is decreasing year by year, the death rate for this …

Targeting PI3K/AKT/mTOR and MAPK signaling pathways in gastric cancer

DT Morgos, C Stefani, D Miricescu, M Greabu… - International Journal of …, 2024 - mdpi.com
Gastric cancer (GC) is the fourth leading cause of death worldwide, with more than 1 million
cases diagnosed every year. Helicobacter pylori represents the main risk factor, being …

Association of CLDN18 protein expression with clinicopathological features and prognosis in advanced gastric and gastroesophageal junction adenocarcinomas

A Pellino, S Brignola, E Riello, M Niero… - Journal of Personalized …, 2021 - mdpi.com
Simple Summary Claudin-18 is a tight junction protein expressed in various cancer types
including gastric and gastroesophageal junction cancer. The claudin-18.2 isoform …

KDM6B promotes gastric carcinogenesis and metastasis via upregulation of CXCR4 expression

F Liu, Y Wang, Z Yang, X Cui, L Zheng, Y Fu… - Cell Death & …, 2022 - nature.com
KDM6B (Lysine-specific demethylase 6B) is a histone lysine demethyltransferase that plays
a key role in many types of cancers. However, its potential role in gastric cancer (GC) …

Alteration of gastric microbiota and transcriptome in a rat with gastric intestinal metaplasia induced by deoxycholic acid

Z Xu, L Xiao, S Wang, Y Cheng, J Wu, Y Meng… - Frontiers in …, 2023 - frontiersin.org
Objective Bile reflux plays a key role in the development of gastric intestinal metaplasia
(GIM), an independent risk factor of gastric cancer. Here, we aimed to explore the biological …

Identification of miR-143-3p as a diagnostic biomarker in gastric cancer

Y Ju, GE Choi, MW Lee, M Jeong, H Kwon… - BMC Medical …, 2023 - Springer
Background Gastric cancer (GC) is among the most common types of gastrointestinal
cancers and has a high incidence and mortality around the world. To suppress the …

A practical approach for PD-L1 evaluation in gastroesophageal cancer

V Angerilli, M Fassan, P Parente, I Gullo… - …, 2022 - pmc.ncbi.nlm.nih.gov
PD-L1 is an established predictive immunohistochemical biomarker of response to immune
checkpoint inhibitors. At present, PD-L1 is routinely assessed on biopsy samples of …

Clinical progress of anti-angiogenic targeted therapy and combination therapy for gastric cancer

D Xu, Y Luo, P Wang, J Li, L Ma, J Huang… - Frontiers in …, 2023 - frontiersin.org
The incidence of gastric cancer is increasing year by year. Most gastric cancers are already
in the advanced stage with poor prognosis when diagnosed, which means the current …

Circ_0008287 promotes immune escape of gastric cancer cells through impairing microRNA-548c-3p-dependent inhibition of CLIC1

B Li, L Liang, Y Chen, J Liu, Z Wang, Y Mao… - International …, 2022 - Elsevier
Background Analyses in silico suggested the upregulation of a circular RNA (circRNA),
circ_0008287, in gastric cancer and possible interactions among microRNA (miR)-548c-3p …

(-)-Asarinin alleviates gastric precancerous lesions by promoting mitochondrial ROS accumulation and inhibiting the STAT3 signaling pathway

M Zhao, Y Wen, Y Yang, H Pan, S Xie, C Shen, W Liao… - Phytomedicine, 2024 - Elsevier
Abstract Background (-)-Asarinin (Asarinin) is the primary component in the extract of the
herb Asarum sieboldii Miq. It possesses various functions, including pain relief, anti-viral and …