The tumor necrosis factor (TNF) and TNF receptor (TNFR) superfamilies (TNFSF/TNFRSF)
include 19 ligands and 29 receptors that play important roles in the modulation of cellular …

Cytokines related to tumor necrosis factor (TNF) provide a communication network essential
for coordinating multiple cell types into an effective host defense system against pathogens …

Background Tulisokibart is a tumor necrosis factor–like cytokine 1A (TL1A) monoclonal
antibody in development for the treatment of moderately to severely active ulcerative colitis …

MAIT cells are an unconventional T cell population that can be activated through both TCR-
dependent and TCR-independent mechanisms. Here, we examined the impact of …

The cytokine responses characterizing the inflammatory bowel diseases are the key
pathophysiologic elements that govern the initiation, evolution, and, ultimately, the resolution …

Traditionally, Crohn's disease has been associated with a Th1 cytokine profile, while Th2
cytokines are modulators of ulcerative colitis. This concept has been challenged by the …

Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative
colitis (UC), represents a group of chronic disorders characterized by inflammation of the …

The incidence of inflammatory bowel diseases (IBD) worldwide has resulted in a global
public health challenge. Intestinal fibrosis leading to stricture formation and bowel …

Cytokines are indispensable signals of the mucosa-associated immune system for
maintaining normal gut homeostasis. An imbalance of their profile in favour of inflammation …

The inflammatory bowel diseases (IBDs), Crohn's disease (CD) and ulcerative colitis, are
chronic inflammatory disorders of the digestive tract. The pathogenesis of IBD is …