Antimicrobial peptides–Advances in development of therapeutic applications

HX Luong, TT Thanh, TH Tran - Life sciences, 2020 - Elsevier
The severe infection is becoming a significant health problem which threaten the lives of
patients and the safety and economy of society. In the way of finding new strategy …

[HTML][HTML] Advances in development of antimicrobial peptidomimetics as potential drugs

N Molchanova, PR Hansen, H Franzyk - Molecules, 2017 - mdpi.com
The rapid emergence of multidrug-resistant pathogens has evolved into a global health
problem as current treatment options are failing for infections caused by pan-resistant …

[HTML][HTML] Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides

I Greco, N Molchanova, E Holmedal, H Jenssen… - Scientific reports, 2020 - nature.com
The use of non-standard toxicity models is a hurdle in the early development of antimicrobial
peptides towards clinical applications. Herein we report an extensive in vitro and in vivo …

[HTML][HTML] Halogenation as a tool to tune antimicrobial activity of peptoids

N Molchanova, JE Nielsen, KB Sørensen… - Scientific reports, 2020 - nature.com
Antimicrobial peptides have attracted considerable interest as potential new class of
antibiotics against multi-drug resistant bacteria. However, their therapeutic potential is …

[HTML][HTML] Exploring the role of unnatural amino acids in antimicrobial peptides

R Oliva, M Chino, K Pane, V Pistorio, A De Santis… - Scientific reports, 2018 - nature.com
Cationic antimicrobial peptides (CAMPs) are a promising alternative to treat multidrug-
resistant bacteria, which have developed resistance to all the commonly used antimicrobial …

[HTML][HTML] Natural and synthetic halogenated amino acids—Structural and bioactive features in antimicrobial peptides and peptidomimetics

M Mardirossian, M Rubini, MFA Adamo, M Scocchi… - Molecules, 2021 - mdpi.com
The 3D structure and surface characteristics of proteins and peptides are crucial for
interactions with receptors or ligands and can be modified to some extent to modulate their …

Recent advances in the development of anti-infective peptoids

KL Bicker, SL Cobb - Chemical Communications, 2020 - pubs.rsc.org
In the search for new sources of antimicrobials many researchers have investigated
antimicrobial peptides (AMPs) as templates for the design of innovative therapeutics …

[HTML][HTML] Antimicrobial peptide mimics for clinical use: does size matter?

J Svenson, N Molchanova, CI Schroeder - Frontiers in Immunology, 2022 - frontiersin.org
The search for efficient antimicrobial therapies that can alleviate suffering caused by
infections from resistant bacteria is more urgent than ever before. Infections caused by multi …

[HTML][HTML] Antimicrobial peptides against bacterial pathogens: Innovative delivery nanosystems for pharmaceutical applications

E Imperlini, F Massaro, F Buonocore - Antibiotics, 2023 - mdpi.com
The introduction of antibiotics has revolutionized the treatment and prevention of microbial
infections. However, the global spread of pathogens resistant to available antibiotics is a …

[HTML][HTML] S100 proteins as novel therapeutic targets in psoriasis and other autoimmune diseases

K Kurpet, G Chwatko - Molecules, 2022 - mdpi.com
Psoriasis is one of the most common inflammatory skin diseases affecting about 1–3% of the
population. One of the characteristic abnormalities in psoriasis is the excessive production of …