Endosomes are dynamic intracellular compartments that control the sorting of a constant
stream of different transmembrane cargos either for ESCRT‐mediated degradation or for …

The highly conserved retromer complex controls the fate of hundreds of receptors that pass
through the endolysosomal system and is a central regulatory node for diverse metabolic …

The Commander complex is required for endosomal recycling of diverse transmembrane
cargos and is mutated in Ritscher-Schinzel syndrome. It comprises two sub-assemblies …

Celastrol, a bioactive molecule extracted from the Tripterygium wilfordii plant, has been
shown to exhibit anti-inflammatory properties. However, its mechanism of action has not …

The recycling of membrane proteins from endosomes to the cell surface is vital for cell
signaling and survival. Retriever, a trimeric complex of vacuolar protein-sorting-associated …

Protein recycling through the endolysosomal system relies on molecular assemblies that
interact with cargo proteins, membranes, and effector molecules. Among them, the …

The Commander complex, a 16-protein assembly, plays multiple roles in cell homeostasis,
cell cycle and immune response. It consists of copper-metabolism Murr1 domain proteins …

The emergence of eukaryotes from ancient prokaryotic lineages embodied a remarkable
increase in cellular complexity. While prokaryotes operate simple systems to connect DNA to …

Cell surface receptors control how cells respond to their environment. Many cell surface
receptors recycle from endosomes to the plasma membrane via a recently discovered …

Background Despite overall improvement in breast cancer patient outcomes from earlier
diagnosis and personalised treatment approaches, some patients continue to experience …