Hypoxia plays an important role in the development of many infectious, inflammatory, and
tumor diseases. The predisposition to such disorders is mostly provided by differences in …

Obstructive sleep apnea (OSA) is the most common respiratory disorder of sleep. The vast
majority (> 80%) of adults with moderate to severe OSA remain undiagnosed. The economic …

Obstructive sleep apnea (OSA) is a common sleep disorder, effecting 17% of the total
population and 40–70% of the obese population (,). Multiple studies have identified OSA as …

Simple Summary The complex signaling networks that different cancers utilize for cell
survival remain poorly understood. A major problem is the complexity of the tumor …

Key points Obstructive sleep apnoea (OSA) is characterized by intermittent hypoxia, which
causes oxidative stress and inflammation and increases the risk of cardiovascular disease …

Chronic intermittent hypoxia (CIH) is the dominant pathological feature of human obstructive
sleep apnoea (OSA), which is highly prevalent and associated with cardiovascular and renal …

Obstructive sleep apnea is a chronic and prevalent condition that is associated with
endothelial dysfunction, atherosclerosis, and imposes excess overall cardiovascular risk …

Background and aims Chronic intermittent hypoxia (CIH) exposure causes atherosclerosis,
although the underlying mechanisms are poorly understood. This study defines the role of …

The pulmonary circulation responds to hypoxia with vasoconstriction, a mechanism that
helps to adapt to short-lived hypoxic episodes. When sustained, hypoxic pulmonary …

Reactive oxygen and nitrogen species (RONS such as H 2 O 2, nitric oxide) confer redox
regulation of essential cellular functions (eg differentiation, proliferation, migration …