The immunobiology of preterm labor and birth: intra-amniotic inflammation or breakdown of maternal–fetal homeostasis

N Gomez-Lopez, J Galaz, D Miller… - …, 2022 - rep.bioscientifica.com
In brief The syndrome of preterm labor comprises multiple established and novel etiologies.
This review summarizes the distinct immune mechanisms implicated in preterm labor and …

Pre‐eclampsia: fitting together the placental, immune and cardiovascular pieces

JL James, GS Whitley, JE Cartwright - The Journal of pathology, 2010 - Wiley Online Library
The success of pregnancy is a result of countless ongoing interactions between the placenta
and the maternal immune and cardiovascular systems. Pre‐eclampsia is a serious …

Decidual leucocyte populations in early to late gestation normal human pregnancy

PJ Williams, RF Searle, SC Robson, BA Innes… - Journal of reproductive …, 2009 - Elsevier
Most research on human decidual leucocytes to date has focused on the predominant
CD56+ uterine natural killer (uNK) cell population in early pregnancy. Few reports have …

Invasion of the leukocytes into the fetal-maternal interface during pregnancy

N Gomez-Lopez, LJ Guilbert… - Journal of leukocyte …, 2010 - academic.oup.com
Review of mechanisms of uterine leukocyte infiltration and the potential roles of each
subpopulation of leukocytes in relation to pregnancy and parturition. No other organ in the …

Maternal and fetal T cells in term pregnancy and preterm labor

D Miller, M Gershater, R Slutsky, R Romero… - Cellular & Molecular …, 2020 - nature.com
Pregnancy is a state of immunological balance during which the mother and the developing
fetus must tolerate each other while maintaining sufficient immunocompetence to ward off …

Vascular endothelial growth factor C facilitates immune tolerance and endovascular activity of human uterine NK cells at the maternal-fetal interface

SS Kalkunte, TF Mselle, WE Norris, CR Wira… - The Journal of …, 2009 - journals.aai.org
Although replete with cytotoxic machinery, uterine NK (uNK) cells remain tolerant at the
maternal-fetal interface. The mechanisms that facilitate the uNK cell tolerance are largely …

Dynamic changes in uterine NK cell subset frequency and function over the menstrual cycle and pregnancy

EM Whettlock, EV Woon, AO Cuff, B Browne… - Frontiers in …, 2022 - frontiersin.org
Uterine natural killer cells (uNK) play an important role in promoting successful pregnancy
by regulating trophoblast invasion and spiral artery remodelling in the first trimester …

Tim-3 is upregulated in NK cells during early pregnancy and inhibits NK cytotoxicity toward trophoblast in galectin-9 dependent pathway

J Sun, M Yang, Y Ban, W Gao, B Song, Y Wang… - PloS one, 2016 - journals.plos.org
NK cells accumulate at the maternal-fetal interface (MFI) and play essential roles in
maintaining immune tolerance during pregnancy. The mechanisms that facilitate NK cells …

The costimulatory signal upregulation is associated with Th1 bias at the maternal–fetal interface in human miscarriage

LP Jin, DX Fan, T Zhang, PF Guo… - American journal of …, 2011 - Wiley Online Library
Citation Jin L‐P, Fan D‐X, Zhang T, Guo P‐F, Li D‐J. The costimulatory signal upregulation
is associated with Th1 bias at the maternal–fetal interface in human miscarriage. Am J …

Natural killer cells and reproductive failure—theory, practice and prejudice

R Rai, G Sacks, G Trew - Human reproduction, 2005 - academic.oup.com
The relationship between peripheral blood natural killer (NK) cells and reproductive failure
is one of the most controversial areas in reproductive medicine. Amidst much publicity …