Multi-cancer early detection test in symptomatic patients referred for cancer investigation in England and Wales (SYMPLIFY): a large-scale, observational cohort study

BD Nicholson, J Oke, PS Virdee, DA Harris… - The Lancet …, 2023 - thelancet.com
Background Analysis of circulating tumour DNA could stratify cancer risk in symptomatic
patients. We aimed to evaluate the performance of a methylation-based multicancer early …

Variation in suspected cancer referral pathways in primary care: comparative analysis across the International Benchmarking Cancer Partnership

C Lynch, S Harrison, JD Emery, C Clelland… - British Journal of …, 2023 - bjgp.org
Background International variations in cancer outcomes persist and may be influenced by
differences in the accessibility and organisation of cancer patient pathways. More evidence …

The pathway and characteristics of patients with non-specific symptoms of cancer: a systematic review

E Jensen, JK Kristensen, RT Bjerglund, SP Johnsen… - BMC cancer, 2022 - Springer
Background Non-specific symptoms are common and often sign of a non-serious disease.
Because of this, patients with non-specific symptoms of cancer (NSSC) present a challenge …

Inequalities in cancer mortality trends in people with type 2 diabetes: 20 year population-based study in England

S Ling, F Zaccardi, E Issa, MJ Davies, K Khunti… - Diabetologia, 2023 - Springer
Aims/hypothesis The aim of this study was to describe the long-term trends in cancer
mortality rates in people with type 2 diabetes based on subgroups defined by …

Metabolomic biomarkers in blood samples identify cancers in a mixed population of patients with nonspecific symptoms

JR Larkin, S Anthony, VA Johanssen, T Yeo… - Clinical Cancer …, 2022 - AACR
Purpose: Early diagnosis of cancer is critical for improving patient outcomes, but cancers
may be hard to diagnose if patients present with nonspecific signs and symptoms. We have …

Conceptual framework to guide early diagnosis programs for symptomatic cancer as part of global cancer control

MM Koo, K Unger-Saldaña, AD Mwaka… - JCO global …, 2021 - ascopubs.org
Diagnosing cancer earlier can enable timely treatment and optimize outcomes. Worldwide,
national cancer control plans increasingly encompass early diagnosis programs for …

Do presenting symptoms, use of pre-diagnostic endoscopy and risk of emergency cancer diagnosis vary by comorbidity burden and type in patients with colorectal …

SB Majano, G Lyratzopoulos, B Rachet… - British journal of …, 2022 - nature.com
Background Cancer patients often have pre-existing comorbidities, which can influence
timeliness of cancer diagnosis. We examined symptoms, investigations and emergency …

Performance of a cell-free DNA-based multi-cancer detection test in individuals presenting with symptoms suspicious for cancers

AH Bryce, DD Thiel, MV Seiden, D Richards… - JCO Precision …, 2023 - ascopubs.org
PURPOSE A multi-cancer detection test using a targeted methylation assay and machine
learning classifiers was validated and optimized for screening in prospective, case …

Risk of cancer and serious disease in Danish patients with urgent referral for serious non-specific symptoms and signs of cancer in Funen 2014–2021

RB Grønnemose, PS Hansen… - British Journal of …, 2024 - nature.com
Background In 2011, as the first European country, Denmark introduced the non-organ-
specific cancer patient pathway (CPP) for patients presenting with non-specific symptoms …

Primary care blood tests before cancer diagnosis: National Cancer Diagnosis Audit data

BM Cranfield, MM Koo, GA Abel, R Swann… - British Journal of …, 2023 - bjgp.org
Background Blood tests can support the diagnostic process in patients with cancer but how
often they are used is unclear. Aim To explore use of common blood tests before cancer …