We first proposed the mitochondrial cascade hypothesis of sporadic Alzheimer's disease
(AD) in 2004. Our core assumptions were a person's genes determine baseline …

The recent failures of potential disease-modifying drugs for Alzheimer's disease (AD) may
reflect the fact that the enrolled participants in clinical trials are already too advanced to …

The purpose of this study was to use serial imaging to gain insight into the sequence of
pathologic events in Alzheimer's disease, and the clinical features associated with this …

Neural stem cell (NSC) transplantation represents an unexplored approach for treating
neurodegenerative disorders associated with cognitive decline such as Alzheimer disease …

Introduction This study examines the utility of a multipanel of cerebrospinal fluid (CSF)
biomarkers complementing Alzheimer's disease (AD) biomarkers in a clinical research …

The positron emission tomography (PET) radiotracer Pittsburgh Compound-B (PiB) binds
with high affinity to β-pleated sheet aggregates of the amyloid-β (Aβ) peptide in vitro. The in …

To date, most diagnostic imaging comparisons between amyloid labelling ligands and other
imaging modalities have been between the use of amyloid labelling ligand 11C Pittsburgh …

In Alzheimer disease (AD), which is the most common cause of dementia, the underlying
disease pathology most probably precedes the onset of cognitive symptoms by many years …

High-dimensional pattern classification was applied to baseline and multiple follow-up MRI
scans of the Alzheimer's Disease Neuroimaging Initiative (ADNI) participants with mild …

Background: Patients with amnestic mild cognitive impairment (MCI) represent an important
clinical group as they are at increased risk of developing Alzheimer disease (AD). 11C-PIB …