Implications of GABAergic neurotransmission in Alzheimer's disease
Y Li, H Sun, Z Chen, H Xu, G Bu… - Frontiers in aging …, 2016 - frontiersin.org
Alzheimer's disease (AD) is characterized pathologically by the deposition of β-amyloid
peptides (Aβ) and the accumulation of neurofibrillary tangles (NFTs) composed of hyper …
peptides (Aβ) and the accumulation of neurofibrillary tangles (NFTs) composed of hyper …
[HTML][HTML] Making the final cut: pathogenic amyloid-β peptide generation by γ-secretase
H Steiner, A Fukumori, S Tagami, M Okochi - Cell Stress, 2018 - ncbi.nlm.nih.gov
Alzheimers disease (AD) is a devastating neurodegenerative disease of the elderly
population. Genetic evidence strongly suggests that aberrant generation and/or clearance of …
population. Genetic evidence strongly suggests that aberrant generation and/or clearance of …
Unraveling the complexity of γ-secretase
MS Wolfe - Seminars in cell & developmental biology, 2020 - Elsevier
Abstract γ-Secretase was initially defined as a proteolytic activity that cleaves within the
transmembrane of the amyloid precursor protein (APP) to produce the amyloid β-peptide of …
transmembrane of the amyloid precursor protein (APP) to produce the amyloid β-peptide of …
Physiological and pathological roles of the γ-secretase complex
CM Carroll, YM Li - Brain research bulletin, 2016 - Elsevier
Gamma-secretase (GS) is an enzyme complex that cleaves numerous substrates, and it is
best known for cleaving amyloid precursor protein (APP) to form amyloid-beta (Aβ) peptides …
best known for cleaving amyloid precursor protein (APP) to form amyloid-beta (Aβ) peptides …
Functional and topological analysis of PSENEN, the fourth subunit of the γ-secretase complex
L Serneels, L Bammens, A Zwijsen, A Tolia… - Journal of Biological …, 2024 - ASBMB
The γ-secretase complexes are intramembrane cleaving proteases involved in the
generation of the Aβ peptides in Alzheimer's disease. The complex consists of four subunits …
generation of the Aβ peptides in Alzheimer's disease. The complex consists of four subunits …
[HTML][HTML] The critical role of γ-secretase and its inhibitors in cancer and cancer therapeutics
C Song, J Zhang, C Xu, M Gao, N Li… - International Journal of …, 2023 - ncbi.nlm.nih.gov
As a multi-substrate transmembrane protease, γ-secretase exists widely in various cells. It
controls multiple important cellular activities through substrate cleavage. γ-secretase …
controls multiple important cellular activities through substrate cleavage. γ-secretase …
Characterizing the structural ensemble of γ-secretase using a multiscale molecular dynamics approach
γ-Secretase is an intramembrane-cleaving aspartyl protease that plays an essential role in
the processing of a variety of integral membrane proteins. Its role in the ultimate cleavage …
the processing of a variety of integral membrane proteins. Its role in the ultimate cleavage …
BACE1 SUMOylation deregulates phosphorylation and ubiquitination in Alzheimer's disease pathology
Y Zhao, H Zhou, Y Zhao, Z Liang, X Gong… - Journal of …, 2023 - Wiley Online Library
BACE1 is essential for the generation of amyloid‐β (Aβ) that likely initiates the toxicity in
Alzheimer's disease (AD). BACE1 activity is mainly regulated by post‐translational …
Alzheimer's disease (AD). BACE1 activity is mainly regulated by post‐translational …
Tangeretin inhibits BACE1 activity and attenuates cognitive impairments in AD model mice
J Bao, Z Liang, X Gong, Y Zhao, M Wu… - Journal of agricultural …, 2022 - ACS Publications
Tangeretin (TAN) exhibits many bioactivities, including neuroprotective effects. However, the
efficacy of TAN in Alzheimer's disease (AD) has not been sufficiently investigated. In the …
efficacy of TAN in Alzheimer's disease (AD) has not been sufficiently investigated. In the …
Cryo-EM structures of human γ-secretase
Highlights•Methods on sample preparation and electron microscopy of human γ-
secretase.•A summary of cryo-EM structures of human γ-secretase.•Functional insights …
secretase.•A summary of cryo-EM structures of human γ-secretase.•Functional insights …