Alzheimer's disease (AD) is characterized pathologically by the deposition of β-amyloid
peptides (Aβ) and the accumulation of neurofibrillary tangles (NFTs) composed of hyper …

Alzheimers disease (AD) is a devastating neurodegenerative disease of the elderly
population. Genetic evidence strongly suggests that aberrant generation and/or clearance of …

Abstract γ-Secretase was initially defined as a proteolytic activity that cleaves within the
transmembrane of the amyloid precursor protein (APP) to produce the amyloid β-peptide of …

Gamma-secretase (GS) is an enzyme complex that cleaves numerous substrates, and it is
best known for cleaving amyloid precursor protein (APP) to form amyloid-beta (Aβ) peptides …

The γ-secretase complexes are intramembrane cleaving proteases involved in the
generation of the Aβ peptides in Alzheimer's disease. The complex consists of four subunits …

As a multi-substrate transmembrane protease, γ-secretase exists widely in various cells. It
controls multiple important cellular activities through substrate cleavage. γ-secretase …

γ-Secretase is an intramembrane-cleaving aspartyl protease that plays an essential role in
the processing of a variety of integral membrane proteins. Its role in the ultimate cleavage …

BACE1 is essential for the generation of amyloid‐β (Aβ) that likely initiates the toxicity in
Alzheimer's disease (AD). BACE1 activity is mainly regulated by post‐translational …

Tangeretin (TAN) exhibits many bioactivities, including neuroprotective effects. However, the
efficacy of TAN in Alzheimer's disease (AD) has not been sufficiently investigated. In the …

Highlights•Methods on sample preparation and electron microscopy of human γ-
secretase.•A summary of cryo-EM structures of human γ-secretase.•Functional insights …