Toward a better understanding of the mechanisms and pathophysiology of anhedonia: are we ready for translation?
DA Pizzagalli - American Journal of Psychiatry, 2022 - Am Psychiatric Assoc
Anhedonia—the loss of pleasure or lack of reactivity to pleasurable stimuli—remains a
formidable treatment challenge across neuropsychiatric disorders. In major depressive …
formidable treatment challenge across neuropsychiatric disorders. In major depressive …
The biology of human resilience: Opportunities for enhancing resilience across the life span
Recent scientific and technological advances have brought us closer to being able to apply
a true biopsychosocial approach to the study of resilience in humans. Decades of research …
a true biopsychosocial approach to the study of resilience in humans. Decades of research …
[HTML][HTML] Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2
A single sub-anesthetic dose of ketamine produces a rapid and sustained antidepressant
response, yet the molecular mechanisms responsible for this remain unclear. Here, we …
response, yet the molecular mechanisms responsible for this remain unclear. Here, we …
Neurobiology of resilience: interface between mind and body
Stress-related neuropsychiatric disorders, such as major depressive disorder and
posttraumatic stress disorder, exact enormous socioeconomic and individual consequences …
posttraumatic stress disorder, exact enormous socioeconomic and individual consequences …
Resilience in the age of COVID-19
H Kaye-Kauderer, JH Feingold, A Feder… - BJPsych …, 2021 - cambridge.org
Resilience is broadly defined as the ability to bounce back from adversity or trauma. Recent
advances in resilience research have shifted away from merely describing individual …
advances in resilience research have shifted away from merely describing individual …
Role of mesolimbic brain-derived neurotrophic factor in depression
Brain-derived neurotrophic factor (BDNF) is widely accepted as being critical for neural and
synaptic plasticity throughout the nervous system. Recent work has shown that BDNF in the …
synaptic plasticity throughout the nervous system. Recent work has shown that BDNF in the …
Selective kappa-opioid antagonism ameliorates anhedonic behavior: Evidence from the Fast-fail Trial in Mood and Anxiety Spectrum Disorders (FAST-MAS)
Anhedonia remains a major clinical issue for which there is few effective interventions.
Untreated or poorly controlled anhedonia has been linked to worse disease course and …
Untreated or poorly controlled anhedonia has been linked to worse disease course and …
Activation of parabrachial nucleus-ventral tegmental area pathway underlies the comorbid depression in chronic neuropathic pain in mice
L Zhang, J Wang, C Niu, Y Zhang, T Zhu, D Huang… - Cell reports, 2021 - cell.com
Depression symptoms are often found in patients suffering from chronic pain, a
phenomenon that is yet to be understood mechanistically. Here, we systematically …
phenomenon that is yet to be understood mechanistically. Here, we systematically …
Impact of the KCNQ2/3 channel opener ezogabine on reward circuit activity and clinical symptoms in depression: results from a randomized controlled trial
Objective: Preclinical studies point to the KCNQ2/3 potassium channel as a novel target for
the treatment of depression and anhedonia, a reduced ability to experience pleasure. The …
the treatment of depression and anhedonia, a reduced ability to experience pleasure. The …
Ion channel dysfunction and neuroinflammation in migraine and depression
E Eren-Koçak, T Dalkara - Frontiers in Pharmacology, 2021 - frontiersin.org
Migraine and major depression are debilitating disorders with high lifetime prevalence rates.
Interestingly these disorders are highly comorbid and show significant heritability …
Interestingly these disorders are highly comorbid and show significant heritability …