The diverse and complex roles of NF-κB subunits in cancer
ND Perkins - Nature Reviews Cancer, 2012 - nature.com
It is only recently that the full importance of nuclear factor-κB (NF-κB) signalling to cancer
development has been understood. Although much attention has focused on the upstream …
development has been understood. Although much attention has focused on the upstream …
Acylhydrazones and their biological activity: a review
LI Socea, SF Barbuceanu, EM Pahontu, AC Dumitru… - Molecules, 2022 - mdpi.com
Due to the structure of acylhydrazones both by the pharmacophore–CO–NH–N= group and
by the different substituents present in the molecules of compounds of this class, various …
by the different substituents present in the molecules of compounds of this class, various …
The Magic Methyl and Its Tricks in Drug Discovery and Development
One of the key scientific aspects of small-molecule drug discovery and development is the
analysis of the relationship between its chemical structure and biological activity …
analysis of the relationship between its chemical structure and biological activity …
Crystal structure, Hirshfeld surface analysis, DFT and molecular docking studies on benzohydrazide derivatives as potential inhibitors of prostate cancer
HA Arjun, RK Rajan, R Elancheran… - Chemical Data …, 2020 - Elsevier
Single crystals of (E)-N'-((1‑chloro-3, 4-dihydronaphthalen-2-yl) methylene)-3-nitro
benzohydrazide and (E)-3‑chloro-N'-((1‑chloro-3, 4dihydronaphthalen-2-yl) methylene) …
benzohydrazide and (E)-3‑chloro-N'-((1‑chloro-3, 4dihydronaphthalen-2-yl) methylene) …
NF-κB-IKKβ pathway as a target for drug development: realities, challenges and perspectives
RHCN Freitas, CAM Fraga - Current drug targets, 2018 - ingentaconnect.com
Background: Nuclear factor ΚB (NF-ΚB) comprises a family of proteins that act as
transcription factors promoting the expression of many genes. Activation of NF-ΚB …
transcription factors promoting the expression of many genes. Activation of NF-ΚB …
Pronounced Magnetic Bistability in Highly Cooperative Mononuclear [Fe(Lnpdtz)2(NCX)2] Complexes
J Kiehl, T Hochdörffer, LM Carrella… - Inorganic …, 2022 - ACS Publications
Molecular materials that exhibit stimuli-responsive bistability are promising candidates for
the development of molecular switches and sensors. We herein report on the coexistence of …
the development of molecular switches and sensors. We herein report on the coexistence of …
Acylhydrazone derivatives: a patent review
Introduction: The N-acylhydrazone (NAH) moiety has been characterized as a privileged
structure, capable of providing ligands points for more than one type of bioreceptor …
structure, capable of providing ligands points for more than one type of bioreceptor …
The NFκB signaling pathway in papillomavirus-induced lesions: friend or foe?
RMG da Costa, MMSM Bastos, R Medeiros… - Anticancer …, 2016 - ar.iiarjournals.org
Papillomaviruses induce a range of benign and malignant lesions in their hosts, including
cervical cancer, that is associated with high-risk human papillomavirus (HPV) types. The …
cervical cancer, that is associated with high-risk human papillomavirus (HPV) types. The …
Discovery of naphthyl‐N‐acylhydrazone p38α MAPK inhibitors with in vivo anti‐inflammatory and anti‐TNF‐α activity
RHCN Freitas, NM Cordeiro… - Chemical biology & …, 2018 - Wiley Online Library
Protein kinases constitute attractive therapeutic targets for development of new prototypes to
treat different chronic diseases. Several available drugs, like tinibs, are tyrosine kinase …
treat different chronic diseases. Several available drugs, like tinibs, are tyrosine kinase …
Novel Regioisomeric Analogues of Naphthyl-N-Acylhydrazone Derivatives and Their Anti-Inflammatory Effects
D da Costa Salomé, RHCN de Freitas… - International Journal of …, 2022 - mdpi.com
Background: When homeostasis is disturbed it can result in a pathological event named
inflammation. The main drugs used in the treatment consist of non-steroidal and steroidal …
inflammation. The main drugs used in the treatment consist of non-steroidal and steroidal …