It is only recently that the full importance of nuclear factor-κB (NF-κB) signalling to cancer
development has been understood. Although much attention has focused on the upstream …

Due to the structure of acylhydrazones both by the pharmacophore–CO–NH–N= group and
by the different substituents present in the molecules of compounds of this class, various …

One of the key scientific aspects of small-molecule drug discovery and development is the
analysis of the relationship between its chemical structure and biological activity …

Single crystals of (E)-N'-((1‑chloro-3, 4-dihydronaphthalen-2-yl) methylene)-3-nitro
benzohydrazide and (E)-3‑chloro-N'-((1‑chloro-3, 4dihydronaphthalen-2-yl) methylene) …

Background: Nuclear factor ΚB (NF-ΚB) comprises a family of proteins that act as
transcription factors promoting the expression of many genes. Activation of NF-ΚB …

Molecular materials that exhibit stimuli-responsive bistability are promising candidates for
the development of molecular switches and sensors. We herein report on the coexistence of …

Introduction: The N-acylhydrazone (NAH) moiety has been characterized as a privileged
structure, capable of providing ligands points for more than one type of bioreceptor …

Papillomaviruses induce a range of benign and malignant lesions in their hosts, including
cervical cancer, that is associated with high-risk human papillomavirus (HPV) types. The …

Protein kinases constitute attractive therapeutic targets for development of new prototypes to
treat different chronic diseases. Several available drugs, like tinibs, are tyrosine kinase …

Background: When homeostasis is disturbed it can result in a pathological event named
inflammation. The main drugs used in the treatment consist of non-steroidal and steroidal …