Several chemicals, including environmental toxicants and clinically useful drugs, cause
severe cellular damage to different organs of our body through metabolic activation to highly …

The role of gut microbiome in human health and disease is well established. While evidence-
based pharmacological studies utilize a variety of chemical-induced metabolic and …

Background: Silymarin (SIL) has long been utilized to treat a variety of liver illnesses, but
due to its poor water solubility and low membrane permeability, it has a low oral …

Simple Summary Liver fibrosis is a challenging global health problem resulting in a
significant morbidity and mortality rates worldwide due to its rapid progression to cirrhosis …

Mesona blumes polysaccharide (MBP), a primary active component extracted from Mesona
blumes, has a number of bioactivities. Nevertheless, hepatoprotective activity of MBP has …

Background: The main obstacles of silymarin (SIL) application in liver diseases are its low
bioavailability, elevated metabolism, rapid excretion in bile and urine, and inefficient …

Liver diseases are one of the fatal disorders due to the vital role of the liver. Carbon
tetrachloride (CCl4) is the most perceived chemical substance utilized in developing models …

Vinclozolin is one of the most used fungicides in the control of fungi in fruits, vegetables, and
ornamental plants. The effects of its exposure on different organs have been described, but …

The purpose of this research was to evaluate whether maltol could protect from hepatic
injury induced by carbon tetrachloride (CCl4) in vivo by inhibition of apoptosis and …

Aims Mesenchymal stem cell-derived exosomes (MSC-EXOs) have emerged as a promising
approach in regenerative medicine for management of different diseases. However, the …