Zinc coordination complexes as anticancer agents
Zinc, present in all forms of life, is an essential element for humans. It is one of the most
abundant metals in our body. Because of its importance, any malfunctions of its homeostasis …
abundant metals in our body. Because of its importance, any malfunctions of its homeostasis …
Metal drugs and the anticancer immune response
B Englinger, C Pirker, P Heffeter, A Terenzi… - Chemical …, 2018 - ACS Publications
The immune system deploys a multitude of innate and adaptive mechanisms not only to
ward off pathogens but also to prevent malignant transformation (“immune surveillance”) …
ward off pathogens but also to prevent malignant transformation (“immune surveillance”) …
Zinc complexes with nitrogen donor ligands as anticancer agents
The search for anticancer metal-based drugs alternative to platinum derivatives could not
exclude zinc derivatives due to the importance of this metal for the correct functioning of the …
exclude zinc derivatives due to the importance of this metal for the correct functioning of the …
Inhibition of NF-kB/IL-6/JAK2/STAT3 pathway and epithelial-mesenchymal transition in breast cancer cells by azilsartan
Metastatic breast cancer is an incurable form of breast cancer that exhibits high levels of
epithelial-mesenchymal transition (EMT) markers. Angiotensin II has been linked to various …
epithelial-mesenchymal transition (EMT) markers. Angiotensin II has been linked to various …
Lanthanide complexes as anticancer agents: A review
One of the rapidly developing fields now a days in medicine is the application of inorganic
chemistry, elegantly it is seen that the novel therapeutic and diagnostic metals and metal …
chemistry, elegantly it is seen that the novel therapeutic and diagnostic metals and metal …
Elevating the discourse on drug delivery: A fresh perspective on the utilization of coordination chemistry-driven metal-drug conjugates
M Biswas, KK Choudhury, A Banerjee… - Coordination Chemistry …, 2024 - Elsevier
The drug development paradigm needed a significant shift towards utilizing bio-compatible
metal ions to stabilize potent drugs and enable their stimuli-responsive release. Highly …
metal ions to stabilize potent drugs and enable their stimuli-responsive release. Highly …
Zinc coordination compounds with benzimidazole derivatives: Synthesis, structure, antimicrobial activity and potential anticancer application
A Raducka, M Świątkowski, I Korona-Głowniak… - International Journal of …, 2022 - mdpi.com
Developing new, smart drugs with the anticancer activity is crucial, especially for cancers,
which cause the highest mortality in humans. In this paper we describe a series of …
which cause the highest mortality in humans. In this paper we describe a series of …
Are Zn (ii) pincer complexes efficient apoptosis inducers? a deep insight into their activity against A549 lung cancer cells
A Das, M Sankaralingam - Dalton Transactions, 2023 - pubs.rsc.org
To expand the array of chemotherapeutic drugs, earth-abundant metal complexes are found
to be the future direction. In this regard, new zinc (II) complexes 1–3 of 8-aminoquinoline …
to be the future direction. In this regard, new zinc (II) complexes 1–3 of 8-aminoquinoline …
Coordination compounds of biogenic metals as cytotoxic agents in cancer therapy
DA Guk, OO Krasnovskaya… - Russian Chemical …, 2021 - iopscience.iop.org
The review summarizes the data on the structures and methods for the synthesis of
compounds with anticancer activity based on biogenic metals, which can replace platinum …
compounds with anticancer activity based on biogenic metals, which can replace platinum …
Metal-induced oxidative stress: an evidence-based update of advantages and disadvantages
M Khalid, S Hassani, M Abdollahi - Current opinion in toxicology, 2020 - Elsevier
Metals are well distributed in our ecosystem and have several advantages and
disadvantages. Some are well known for inducing oxidative stress by disturbing the cellular …
disadvantages. Some are well known for inducing oxidative stress by disturbing the cellular …