Single-cell transcriptome analysis reveals dynamic cell populations and differential gene expression patterns in control and aneurysmal human aortic tissue
Background: Ascending thoracic aortic aneurysm (ATAA) is caused by the progressive
weakening and dilatation of the aortic wall and can lead to aortic dissection, rupture, and …
weakening and dilatation of the aortic wall and can lead to aortic dissection, rupture, and …
Cellular mechanisms of human atherogenesis: focus on chronification of inflammation and mitochondrial mutations
AM Markin, IA Sobenin, AV Grechko, D Zhang… - Frontiers in …, 2020 - frontiersin.org
Atherosclerosis is one of the most common diseases of the cardiovascular system that leads
to the development of life-threatening conditions, such as heart attack and stroke …
to the development of life-threatening conditions, such as heart attack and stroke …
Circular RNA expression: Its potential regulation and function in abdominal aortic aneurysms
Abdominal aortic aneurysms (AAAs) have posed a great threat to human life, and the
necessity of its monitoring and treatment is decided by symptomatology and/or the aneurysm …
necessity of its monitoring and treatment is decided by symptomatology and/or the aneurysm …
Dynamic alternations of three-dimensional chromatin architecture contribute to phenotypic characteristics of breast muscle in chicken
Z Wang, W Tian, Y Guo, D Wang, Y Zhang… - Communications …, 2024 - nature.com
Breast muscle growth rate and intramuscular fat (IMF) content show apparent differences
between fast-growing broilers and slow-growing indigenous chickens. However, the …
between fast-growing broilers and slow-growing indigenous chickens. However, the …
High Shear Stress Reduces ERG Causing Endothelial-Mesenchymal Transition and Pulmonary Arterial Hypertension
T Shinohara, JR Moonen, YH Chun… - … and Vascular Biology, 2024 - ahajournals.org
BACKGROUND: Computational modeling indicated that pathological high shear stress
(HSS; 100 dyn/cm2) is generated in pulmonary arteries (PAs; 100–500 µm) in congenital …
(HSS; 100 dyn/cm2) is generated in pulmonary arteries (PAs; 100–500 µm) in congenital …
Systematic review of genome-wide association studies of abdominal aortic aneurysm
Background and aims Abdominal aortic aneurysm (AAA) is an important cause of death
worldwide and has an estimated heritability between 70 and 77%. Genome-wide …
worldwide and has an estimated heritability between 70 and 77%. Genome-wide …
Old blood from heterochronic parabionts accelerates vascular aging in young mice: Transcriptomic signature of pathologic smooth muscle remodeling
Vascular aging has a central role in the pathogenesis of cardiovascular diseases
contributing to increased mortality of older adults. There is increasing evidence that, in …
contributing to increased mortality of older adults. There is increasing evidence that, in …
The SNP rs4591246 in pri-miR-1-3p is associated with abdominal aortic aneurysm risk by regulating cell phenotypic transformation via the miR-1-3p/TLR4 axis
T Li, J Jing, L Sun, Y Gong, J Yang, C Ma… - International …, 2023 - Elsevier
Emerging evidence reveals that single nucleotide polymorphism (SNP) within miRNAs can
affect the risk of cardiovascular diseases. However, the role of miRNA SNPs in abdominal …
affect the risk of cardiovascular diseases. However, the role of miRNA SNPs in abdominal …
Pathophysiological aspects of the development of abdominal aortic aneurysm with a special focus on mitochondrial dysfunction and genetic associations
VI Summerhill, VN Sukhorukov, AH Eid… - Biomolecular …, 2021 - degruyter.com
Abdominal aortic aneurysm (AAA) is a complex degenerative vascular disease, with
considerable morbidity and mortality rates among the elderly population. The mortality of …
considerable morbidity and mortality rates among the elderly population. The mortality of …
Targeting complexes of super‑enhancers is a promising strategy for cancer therapy
C Zheng, M Liu, H Fan - Oncology letters, 2020 - spandidos-publications.com
The hyperactivation and overexpression of critical oncogenes is a common occurrence in
multiple types of malignant tumors. Recently, the abnormal activation mechanism of an …
multiple types of malignant tumors. Recently, the abnormal activation mechanism of an …