Cardiovascular diseases are the leading cause of death worldwide. Therefore, the discovery
of induced pluripotent stem cells (iPSCs) and the subsequent generation of human induced …

The term 'mechanosensation'describes the capacity of cells to translate mechanical stimuli
into the coordinated regulation of intracellular signals, cellular function, gene expression …

Purpose: Both cardiomyocytes and cardiac fibroblasts (CF) play essential roles in cardiac
development, function, and remodeling. Properties of 3D co-cultures are incompletely …

Myocardial infarction (MI) is one of the fatal diseases in humans. Its incidence is constantly
increasing annually all over the world. The problem is accompanied by the limited …

Tissue engineering (TE) is a rapidly growing interdisciplinary field, which aims to restore or
improve lost tissue function. Despite that TE was introduced more than 20 years ago …

Heart diseases have become the main killer threatening human health, and various
methods have been developed to study heart disease. Among them, heart-on-a-chip has …

During embryonic morphogenesis, the heart undergoes a complex series of cellular
phenotypic maturations (eg, transition of myocytes from proliferative to quiescent or …

Cardiovascular disease is the number one killer worldwide, with myocardial infarction (MI)
responsible for approximately 1 in 6 deaths. The lack of endogenous regenerative capacity …

Heart diseases are currently the leading cause of death worldwide. The ability to create
cardiovascular tissue has numerous applications in understanding tissue development …

Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CM) may
provide an important bridge between animal models and the intact human myocardium …