The major function of vitamin D in vertebrates is maintenance of calcium homeostasis, but
vitamin D insufficiency has also been linked to an increased risk of hypertension …

Steroids are small and highly important structural or signalling molecules in living organisms
and their metabolism is complex. Due to the multiplicity of enzymes involved there are many …

Background: Measurement of serum androgens is important in adult, geriatric, pediatric
endocrinology, and oncology patients. We developed a liquid chromatography—tandem …

Background Mass spectrometric-based measurements of the steroid metabolome have
been introduced to diagnose disorders featuring abnormal steroidogenesis. Defined …

Liquid chromatography tandem mass spectrometry is one of the most specific techniques
available in clinical laboratories. In the past, immunoassays were the primary methodology …

Automated rapid HPLC tandem mass spectrometry has become the method of choice for
clinical steroid analysis. It is replacing immunoassay techniques in most instances because …

The correct measurement of steroids is vital for the diagnosis of congenital adrenal
hyperplasia (CAH), apparent mineralocorticoid excess, familial hyperaldosteronism type I …

Reference intervals are relied upon by clinicians when interpreting their patients' test results.
Therefore, laboratorians directly contribute to patient care when they report accurate …

Objectives To compare pediatric reference intervals calculated using hospital-based patient
data with those calculated using samples collected from healthy children in the community …

Serum steroid assays are major tools in the clinical evaluation of adrenal disorders. The
main adrenal steroids are routinely measured with immunoassays. However …