Osteocytes are an ancient cell, appearing in fossilized skeletal remains of early fish and
dinosaurs. Despite its relative high abundance, even in the context of nonskeletal cells, the …

Few investigators think of bone as an endocrine gland, even after the discovery that
osteocytes produce circulating fibroblast growth factor 23 that targets the kidney and …

Living organisms are capable of inducing the crystallization and deposition of a wide variety
of minerals, 1 but the vertebrates mainly utilize the calcium phosphates in constructing their …

Osteocytes, the cells residing within the bone matrix and comprising 90% to 95% of the all
bone cells, have long been considered quiescent bystander cells compared to the …

Hypophosphatemia is a genetically heterogeneous disease. Here, we mapped an
autosomal recessive form (designated ARHP) to chromosome 4q21 and identified …

The discovery of fibroblast growth factor 23 (FGF-23) has expanded our understanding of
phosphate and vitamin D homeostasis and provided new insights into the pathogenesis of …

Bone mineralization entails two mineralization phases: primary and secondary
mineralization. Primary mineralization is achieved when matrix vesicles are secreted by …

The identity of the cell type responsive to sclerostin, a negative regulator of bone mass, is
unknown. Since sclerostin is expressed in vivo by mineral‐embedded osteocytes, we tested …

Before osteocytes were recognized as active essential bone cells necessary for bone health,
it was assumed that all the action took place on the bone surface and not within the bone …

Osteocytes actively participate in almost every phase of mineral handling by bone. They
regulate the mineralisation of osteoid during bone formation, and they are also a major …