[HTML][HTML] Candidalysin: discovery and function in Candida albicans infections
Highlights•Candidalysin is the first peptide toxin identified in any human fungal pathogen.•
Candidalysin is critical for Candida albicans mucosal and systemic infections.•Candidalysin …
Candidalysin is critical for Candida albicans mucosal and systemic infections.•Candidalysin …
Candida parapsilosis, an Emerging Fungal Pathogen
Candida parapsilosis is an emerging major human pathogen that has dramatically
increased in significance and prevalence over the past 2 decades, such that C. parapsilosis …
increased in significance and prevalence over the past 2 decades, such that C. parapsilosis …
Candida albicans Secreted Aspartyl Proteinases in Virulence and Pathogenesis
Candida albicans is the most common fungal pathogen of humans and has developed an
extensive repertoire of putative virulence mechanisms that allows successful colonization …
extensive repertoire of putative virulence mechanisms that allows successful colonization …
Hydrolytic enzymes as virulence factors of Candida albicans
M Schaller, C Borelli, HC Korting, B Hube - Mycoses, 2005 - Wiley Online Library
Candida albicans is a facultative pathogenic micro‐organism that has developed several
virulence traits enabling invasion of host tissues and avoidance of host defence …
virulence traits enabling invasion of host tissues and avoidance of host defence …
[HTML][HTML] Candida albicans interactions with epithelial cells and mucosal immunity
Candida albicans interactions with epithelial cells are critical for commensal growth, fungal
pathogenicity and host defence. This review will outline our current understanding of C …
pathogenicity and host defence. This review will outline our current understanding of C …
Protease inhibitors: current status and future prospects
D Leung, G Abbenante, DP Fairlie - Journal of medicinal chemistry, 2000 - ACS Publications
The four major classes of protease enzymes1-4 (aspartic, serine, cysteine, and metallo)
selectively catalyze the hydrolysis of polypeptide bonds. Their control over protein synthesis …
selectively catalyze the hydrolysis of polypeptide bonds. Their control over protein synthesis …
A biphasic innate immune MAPK response discriminates between the yeast and hyphal forms of Candida albicans in epithelial cells
DL Moyes, M Runglall, C Murciano, C Shen, D Nayar… - Cell host & …, 2010 - cell.com
Discriminating between commensal and pathogenic states of opportunistic pathogens is
critical for host mucosal defense and homeostasis. The opportunistic human fungal …
critical for host mucosal defense and homeostasis. The opportunistic human fungal …
Secreted proteases from pathogenic fungi
M Monod, S Capoccia, B Léchenne, C Zaugg… - International Journal of …, 2002 - Elsevier
Many species of human pathogenic fungi secrete proteases in vitro or during the infection
process. Secreted endoproteases belong to the aspartic proteases of the pepsin family …
process. Secreted endoproteases belong to the aspartic proteases of the pepsin family …
Candida albicans proteinases and host/pathogen interactions
Candida infections are common, debilitating and often recurring fungal diseases and a
problem of significant clinical importance. Candida albicans, the most virulent of the …
problem of significant clinical importance. Candida albicans, the most virulent of the …
Candida albicans proteinases: resolving the mystery of a gene family
Fungal infections of mucosal surfaces are extremely common, debilitating and often
recurring diseases, which are frequently caused by the yeast Candida albicans …
recurring diseases, which are frequently caused by the yeast Candida albicans …