One excellent illustration of how a single gene abnormality may result in a spectrum of
disease incidence is the incredible phenotypic variety of β-thalassemia, which spans from …

Background: β-thalassaemia is a disorder caused by mutations in the β-globin gene, leading
to defective production of haemoglobins (Hb) and red blood cells (RBCs). It is characterised …

Both α-and β-thalassaemia syndromes are public health problems in the multi-ethnic
population of Malaysia. To molecularly characterise the α-and β-thalassaemia deletions and …

Hemoglobinopathies such as β-thalassemia (β-thal) and sickle cell anemia (or Hb S [β6 (A3)
Glu→ Val]) impose a major health burden in the Indian population. To determine the …

Hemoglobinopati meliputi kelainan pada struktur dan gangguan sintesis hemoglobin
(thalassemia). Kelainan pada Hb ini merupakan kelainan gen tunggal yang pada awalnya …

Background/Aims: Beta (β)-thalassaemia is a public health problem in Malaysia. The carrier
rate is estimated to be 4.5 by micro-mapping studies particularly among Malays who …

It is generally agreed that the protease inhibitor (PI) alleles PI* S (Val264Glu) and PI* Z
(Lys342Glu) are the most common alpha 1 antitrypsin deficiency variants worldwide, but the …

Introduction: Beta-thalassemia is one of the most prevalent inherited blood diseases among
Iranians. The aim of this study was to elucidate the chromosomal background of beta …

Background: Thalassemia is one of the most common single gene disorders worldwide with
hundreds of mutations involving beta (β)-globin gene alone. Nevertheless, each ethnic …

Summary Introduction In Malaysia, β‐thalassaemia is a common inherited blood disorder in
haemoglobin synthesis with a carrier rate of 4.5%. Currently, PCR‐incorporating techniques …