A review and database of snake venom proteomes

T Tasoulis, GK Isbister - Toxins, 2017 - mdpi.com
Advances in the last decade combining transcriptomics with established proteomics
methods have made possible rapid identification and quantification of protein families in …

Venomics: integrative venom proteomics and beyond

JJ Calvete - Biochemical Journal, 2017 - portlandpress.com
Venoms are integrated phenotypes that evolved independently in, and are used for
predatory and defensive purposes by, a wide phylogenetic range of organisms. The same …

Preclinical evaluation of the efficacy of antivenoms for snakebite envenoming: State-of-the-art and challenges ahead

JM Gutiérrez, G Solano, D Pla, M Herrera, Á Segura… - Toxins, 2017 - mdpi.com
Animal-derived antivenoms constitute the mainstay in the therapy of snakebite envenoming.
The efficacy of antivenoms to neutralize toxicity of medically-relevant snake venoms has to …

Old World Vipers—a review about snake venom proteomics of Viperinae and their variations

M Damm, BF Hempel, RD Süssmuth - Toxins, 2021 - mdpi.com
Fine-tuned by millions of years of evolution, snake venoms have frightened but also
fascinated humanity and nowadays they constitute potential resources for drug …

Unveiling underestimated species diversity within the Central American Coralsnake, a medically important complex of venomous taxa

MJ Jowers, U Smart, S Sánchez-Ramírez… - Scientific Reports, 2023 - nature.com
Coralsnakes of the genus Micrurus are a diverse group of venomous snakes ranging from
the southern United States to southern South America. Much uncertainty remains over the …

The medical threat of mamba envenoming in sub-Saharan Africa revealed by genus-wide analysis of venom composition, toxicity and antivenomics profiling of …

S Ainsworth, D Petras, M Engmark, RD Süssmuth… - Journal of …, 2018 - Elsevier
Mambas (genus Dendroaspis) are among the most feared of the medically important elapid
snakes found in sub-Saharan Africa, but many facets of their biology, including the diversity …

Innovative immunization strategies for antivenom development

E Bermúdez-Méndez, A Fuglsang-Madsen, S Føns… - Toxins, 2018 - mdpi.com
Snakes, scorpions, and spiders are venomous animals that pose a threat to human health,
and severe envenomings from the bites or stings of these animals must be treated with …

Functional proteomic analyses of Bothrops atrox venom reveals phenotypes associated with habitat variation in the Amazon

LF Sousa, JA Portes-Junior, CA Nicolau… - Journal of …, 2017 - Elsevier
Venom variability is commonly reported for venomous snakes including Bothrops atrox.
Here, we compared the composition of venoms from B. atrox snakes collected at Amazonian …

Investigating toxin diversity and abundance in snake venom proteomes

T Tasoulis, TL Pukala, GK Isbister - Frontiers in Pharmacology, 2022 - frontiersin.org
Understanding snake venom proteomes is becoming increasingly important to understand
snake venom biology, evolution and especially clinical effects of venoms and approaches to …

Delayed LY333013 (Oral) and LY315920 (Intravenous) Reverse Severe Neurotoxicity and Rescue Juvenile Pigs from Lethal Doses of Micrurus fulvius (Eastern Coral …

MR Lewin, LL Gilliam, J Gilliam, SP Samuel… - Toxins, 2018 - mdpi.com
There is a clear, unmet need for effective, lightweight, shelf-stable and economical snakebite
envenoming therapies that can be given rapidly after the time of a snake's bite and as …