Classic galactosemia is a genetic disorder that results from profound loss of galactose-1P-
uridylyltransferase (GALT). Affected infants experience a rapid escalation of potentially lethal …

The metabolism of galactose via enzymes of the Leloir pathway: galactokinase, galactose-1-
P uridylyltransferase, and UDP galactose-4′-epimerase, is a process that has been …

Impairment of the human enzyme galactose-1-phosphate uridylyltransferase (GALT) results
in the potentially lethal disorder galactosemia; the biochemical basis of pathophysiology in …

Caloric restriction (CR) is the most compelling example of lifespan extension by external
manipulation. Although the molecular mechanisms remain unknown, the theory of hormesis …

Impairment of the human enzyme UDPgalactose 4‐epimerase (hGALE) results in epimerase‐
deficiency galactosaemia, an inborn error of metabolism with variable biochemical …

In most organisms, galactose is metabolized via the Leloir pathway, which is conserved from
bacteria to mammals. Utilization of galactose requires a close interplay of the metabolic …

UDP-galactose 4′-epimerase (GALE) catalyzes the final step in the Leloir pathway of
galactose metabolism, interconverting UDP-galactose and UDP-glucose. Unlike its …

Galactose is metabolized in humans and other species by the three-enzyme Leloir pathway
comprised of galactokinase (GALK), galactose 1-P uridylyltransferase (GALT), and UDP …

A major role in the regulation of eukaryotic protein-coding genes is played by the gene-
specific transcriptional regulators, which recruit the RNA polymerase II holoenzyme to the …

Integrity of mitochondrial functionality is a key determinant of longevity in several organisms.
In particular, reduced mitochondrial ROS (mtROS) production leading to decreased mtDNA …