In utero electroporation (IUE) is a technique developed in the early 2000s to transfect the
neurons and neural progenitors of embryonic brains, thus enabling continued development …

Focal cortical dysplasia (FCD) is a structural lesion that is the most common anatomical
lesion identified in children, and the second most common in adults with drug-resistant focal …

DEPDC5, the key gene within the mechanistic target of rapamycin (mTOR) pathway, is one
of the most common causative genes in patients with epilepsy and malformation of cortical …

Objective Focal cortical dysplasia (FCD) is the most common malformation causing
refractory focal epilepsy. Surgical removal of the entire dysplastic cortex is crucial for …

Objective Developmental and epileptic encephalopathies (DEEs) can result from dominant,
gain of function variants of neuronal ion channels. More than 450 de novo missense variants …

Objective De novo mutations of the voltage‐gated sodium channel gene SCN8A cause
developmental and epileptic encephalopathy (DEE). Most pathogenic variants result in gain …

Early-onset epilepsy following ischemic stroke is a severe neurological condition, the
pathogenesis of which remains incompletely understood. Recent studies suggest that …

Malformations of cortical development represent a major cause of epilepsy in childhood.
However, the pathological substrate and dynamic changes leading to the development and …

GBM is the most life-threatening neurological disease with annual incidence of∼ 5 cases
per 100,000 people and a median survival of less than 15 months. Seizures are the first …

Objective In sleep-related epilepsy (SRE), epileptic seizures predominantly occur during
sleep, but the clinical characteristics of SRE remain elusive. We aimed to identify the clinical …