Vascular pathologies underpin and intertwine autoimmune rheumatic diseases and
cardiovascular conditions, and atherosclerosis is increasingly recognized as the leading …

Systemic lupus erythematosus (SLE) is an autoimmune disease that has diverse clinical
manifestations, ranging from restricted cutaneous involvement to life-threatening systemic …

The majority of patients with systemic lupus erythematosus (SLE) have high expression of
type I IFN-stimulated genes. Mitochondrial abnormalities have also been reported, but the …

Artificial intelligence (AI)-based predictive models are being used to foster a precision
medicine approach to treat complex chronic diseases such as autoimmune and …

Systemic lupus erythematosus (SLE) is a multisystem, chronic autoimmune disease where
treatment varies by patient and disease activity. Strong preclinical results and clinical …

The pandemic 2019 novel coronavirus disease (COVID-19) shares certain clinical
characteristics with other acute viral infections. We studied the whole-blood transcriptomic …

Although research on rare autoimmune and autoinflammatory diseases has enabled
definition of nonredundant regulators of homeostasis in human immunity, because of the …

Dysregulation of type I interferons (IFNs) has been implicated in the pathogenesis of
systemic lupus erythematosus (SLE) since the late 1970s. The majority of SLE patients …

Systemic lupus erythematosus (SLE) is an incurable autoimmune disease disproportionately
affecting women. A major obstacle in finding targeted therapies for SLE is its remarkable …

Systemic lupus erythematosus (SLE) is an autoimmune disease in which outcomes vary
among different racial groups. We leverage cell-sorted RNA-seq data (CD14+ monocytes, B …