Posttranslational modifications add complexity and diversity to cellular proteomes. One of
the most prevalent modifications across eukaryotes is ubiquitination, which is orchestrated …

Simple Summary The Tribbles proteins are members of CAMK Ser/Thr protein kinase family.
They are evolutionary conserved pseudokinases found in most tissues of eukaryotic …

PKM2 is an important regulator of the aerobic glycolysis that plays a vital role in cancer cell
metabolic reprogramming. In general, Trib2 is considered as a “pseudokinase”, contributing …

Phosphatases are a diverse family of enzymes, comprising at least 10 distinct protein folds.
Like most other enzyme families, many have sequence variations that predict an impairment …

Protein kinase C (PKC) isozymes are maintained in a'ready-to-go'but'safe'autoinhibited
conformation until second messenger binding unleashes an autoinhibitory pseudosubstrate …

Background Erythropoietin-producing hepatocellular (EPH) receptors are the largest known
family of receptor tyrosine kinases characterized in humans. These proteins are involved in …

The understudied members of the druggable proteomes offer promising prospects for drug
discovery efforts. While large-scale initiatives have generated valuable functional …

Simple Summary Due to their central role in many biological processes, studies on protein
kinases are an area of active research. In the last few decades, several inhibitors that target …

Summary Unc-51-like kinase 4 (ULK4) is a pseudokinase that has been linked to the
development of several diseases. Even though sequence motifs required for ATP binding in …

The Eph receptor tyrosine kinase member EphB6 is a pseudokinase, and similar to other
pseudoenzymes has not attracted an equivalent amount of interest as its enzymatically …