Abstract Exportin 1 (XPO1), also known as chromosome region maintenance protein 1,
plays a crucial role in maintaining cellular homeostasis via the regulated export of a range of …

Cancer is a disease caused by the accumulation of genetic and epigenetic changes in two
types of genes: tumor suppressor genes (TSGs) and proto-oncogenes. Extensive research …

Nonalcoholic fatty liver disease (NAFLD) is usually characterized with disrupted bile acid
(BA) homeostasis. However, the exact role of certain BA in NAFLD is poorly understood …

The signal transducer and activator of transcription (STAT) 1 protein plays a key role in the
immune response against viruses and other pathogens by transducing, in the nucleus, the …

RNA has a dual role as an informational molecule and a direct effector of biological tasks.
The latter function is enabled by RNA's ability to adopt complex secondary and tertiary folds …

Cellular homeostasis requires the proper nuclear-cytoplasmic partitioning of large
molecules, which is often deregulated in cancer. XPO1 is an export receptor responsible for …

All eukaryotes rely on selective proteolysis to control the abundance of key regulatory
proteins and maintain a healthy and properly functioning proteome. Most of this turnover is …

The MAPK cascades are central signaling pathways that regulate a wide variety of
stimulated cellular processes, including proliferation, differentiation, apoptosis and stress …

Abstract Interferon-γ (IFN-γ) coordinates a diverse array of cellular programs through
transcriptional regulation of immunologically relevant genes. This article reviews the current …

Influenza A viruses are a major cause of mortality. Given the potential for future lethal
pandemics, effective drugs are needed for the treatment of severe influenza such as that …