Originally, the peroxisomal targeting signal 1 (PTS1) was defined as a tripeptide at the C-
terminus of proteins prone to be imported into the peroxisomal matrix. The corresponding …

Peroxisomes are unique among the organelles of the endomembrane system. Unlike other
organelles that derive most if not all of their proteins from the ER (endoplasmic reticulum) …

Peroxisomes are ubiquitous organelles whose dysfunction causes fatal human diseases.
Most peroxisomal proteins are imported from the cytosol in a folded state by the soluble …

The proper distribution of proteins between the cytosol and various membrane-bound
compartments is crucial for the functionality of eukaryotic cells. This requires the cooperation …

Peroxisomal matrix proteins are posttranslationally imported into peroxisomes with the
peroxisome-targeting signal 1 receptor, Pex5. The longer isoform of Pex5, Pex5L, also …

Peroxisomes are vital metabolic organelles that import their lumenal (matrix) enzymes from
the cytosol using mobile receptors. Surprisingly, the receptors can even import folded …

The peroxisome biogenesis disorders (PBDs) comprise 12 autosomal recessive
complementation groups (CGs). The multisystem clinical phenotype varies widely in severity …

Peroxisomes are organelles that play a central role in lipid metabolism and cellular redox
homeostasis. The import of peroxisomal matrix proteins by peroxisomal targeting signal …

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels (h channels) are the
molecular basis for the current, I h, which contributes crucially to intrinsic neuronal …

Protein translocation across the peroxisomal membrane requires the concerted action of
numerous peroxins. One central component of this machinery is Pex5p, the cycling receptor …