[HTML][HTML] Peroxisome targeting signal 1: is it really a simple tripeptide?
C Brocard, A Hartig - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2006 - Elsevier
Originally, the peroxisomal targeting signal 1 (PTS1) was defined as a tripeptide at the C-
terminus of proteins prone to be imported into the peroxisomal matrix. The corresponding …
terminus of proteins prone to be imported into the peroxisomal matrix. The corresponding …
[HTML][HTML] Multiple pathways for protein transport to peroxisomes
PK Kim, EH Hettema - Journal of molecular biology, 2015 - Elsevier
Peroxisomes are unique among the organelles of the endomembrane system. Unlike other
organelles that derive most if not all of their proteins from the ER (endoplasmic reticulum) …
organelles that derive most if not all of their proteins from the ER (endoplasmic reticulum) …
Protein import into peroxisomes occurs through a nuclear pore–like phase
Peroxisomes are ubiquitous organelles whose dysfunction causes fatal human diseases.
Most peroxisomal proteins are imported from the cytosol in a folded state by the soluble …
Most peroxisomal proteins are imported from the cytosol in a folded state by the soluble …
The similarity between N-terminal targeting signals for protein import into different organelles and its evolutionary relevance
M Kunze, J Berger - Frontiers in physiology, 2015 - frontiersin.org
The proper distribution of proteins between the cytosol and various membrane-bound
compartments is crucial for the functionality of eukaryotic cells. This requires the cooperation …
compartments is crucial for the functionality of eukaryotic cells. This requires the cooperation …
Shuttling mechanism of peroxisome targeting signal type 1 receptor Pex5: ATP-independent import and ATP-dependent export
N Miyata, Y Fujiki - Molecular and cellular biology, 2005 - Taylor & Francis
Peroxisomal matrix proteins are posttranslationally imported into peroxisomes with the
peroxisome-targeting signal 1 receptor, Pex5. The longer isoform of Pex5, Pex5L, also …
peroxisome-targeting signal 1 receptor, Pex5. The longer isoform of Pex5, Pex5L, also …
Towards solving the mystery of peroxisomal matrix protein import
ML Skowyra, P Feng, TA Rapoport - Trends in Cell Biology, 2023 - cell.com
Peroxisomes are vital metabolic organelles that import their lumenal (matrix) enzymes from
the cytosol using mobile receptors. Surprisingly, the receptors can even import folded …
the cytosol using mobile receptors. Surprisingly, the receptors can even import folded …
Peroxisome biogenesis disorders
S Weller, SJ Gould, D Valle - Annual review of genomics and …, 2003 - annualreviews.org
The peroxisome biogenesis disorders (PBDs) comprise 12 autosomal recessive
complementation groups (CGs). The multisystem clinical phenotype varies widely in severity …
complementation groups (CGs). The multisystem clinical phenotype varies widely in severity …
ATP-Dependent Steps in Peroxisomal Protein Import
HW Platta, J Jeske, N Schmidt… - Annual Review of …, 2024 - annualreviews.org
Peroxisomes are organelles that play a central role in lipid metabolism and cellular redox
homeostasis. The import of peroxisomal matrix proteins by peroxisomal targeting signal …
homeostasis. The import of peroxisomal matrix proteins by peroxisomal targeting signal …
Alternatively spliced isoforms of TRIP8b differentially control h channel trafficking and function
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels (h channels) are the
molecular basis for the current, I h, which contributes crucially to intrinsic neuronal …
molecular basis for the current, I h, which contributes crucially to intrinsic neuronal …
Ubiquitination of mammalian Pex5p, the peroxisomal import receptor
AF Carvalho, MP Pinto, CP Grou, IS Alencastre… - Journal of Biological …, 2007 - ASBMB
Protein translocation across the peroxisomal membrane requires the concerted action of
numerous peroxins. One central component of this machinery is Pex5p, the cycling receptor …
numerous peroxins. One central component of this machinery is Pex5p, the cycling receptor …