Focal adhesion kinase (FAK) is both a non-receptor tyrosine kinase and an adaptor protein
that primarily regulates adhesion signalling and cell migration, but FAK can also promote …

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease that typically features a
dramatic desmoplastic reaction, especially fibroblasts. The roles of cancer-associated …

The metastasis is a multistep process in which a small proportion of cancer cells are
detached from the colony to enter into blood cells for obtaining a new place for metastasis …

Simple Summary Stroma modifications observed in solid cancer are now recognized as
critical events for cancer progression and as potential therapeutic or diagnostic targets. The …

The tumor microenvironment plays a pivotal role in tumor initiation and progression by
creating a dynamic interaction with cancer cells. The tumor microenvironment consists of …

Pancreatic ductal adenocarcinoma (PDAC) has a poor 5-year overall survival rate. Patients
with PDAC display limited benefits after undergoing chemotherapy or immunotherapy …

Background: Lymph node (LN) metastasis is common in patients with epithelial ovarian
cancer (EOC) and is associated with poor prognosis. Tumor-associated lymphangiogenesis …

Pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer, is
characterized by poor treatment response and low survival time. The current clinical …

High-grade serous ovarian cancer (HGSOC) is a lethal malignancy characterized by an
immunosuppressive tumor microenvironment containing few tumor infiltrating lymphocytes …

The hyperproliferative tumor stroma of pancreatic ductal adenocarcinoma (PDAC) severely
limits drug permeation and constructs an immunosuppressive microenvironment, causing …