The loss of effectiveness of current antibiotics caused by the development of drug resistance
has become a severe threat to public health. Current widely used antibiotics are surprisingly …

Studying noncanonical intermolecular interactions between a ligand and a protein
constitutes an emerging research field. Identifying synthetically accessible molecular …

Dry age-related macular degeneration and Stargardt disease undergo a known toxic
mechanism caused by carbonyl and oxidative stresses (COS). This is responsible for …

An unusual example of the selective hydrolysis of a cyano group to the corresponding
carboxyl group under mild reaction conditions in the presence of a carboxamide group is …

The first example of an ammonium derivative that causes a specific modification of the active
site of type I dehydroquinase (DHQ1), a dehydratase enzyme that is a promising target for …

A myriad of drug-resistant strains of Helicobacter pylori and adverse drug-reactions create a
big-barrier in the treatment, thereby demanding novel proof-of-concept inhibitors and …

Citrazinic acid is an important substance because of its applicability and its role as a
chemical precursor. The synthetic section of this review stresses the formation of the product …

A multidisciplinary approach was used to identify and optimize a quinazolinedione‐based
ligand that would decrease the flexibility of the substrate‐covering loop (catalytic loop) of the …

A one-pot synthesis of 3-carbamoyl-2-oxo-1, 2-dihydropyridine-4-carboxylic acids has been
developed via the reaction of 4-oxoalkane-1, 1, 2, 2-tetracarbonitriles with water, followed by …

The intracellular pathogen Burkholderia pseudomallei, which is endemic to parts of
southeast Asia and northern Australia, causes the disease melioidosis. Although acute …