Lipids have essential biological functions in the body (eg, providing energy storage, acting
as a signaling molecule, and being a structural component of membranes); however, an …

Phenotypic plasticity has emerged as a major contributor to intra-tumoral heterogeneity and
treatment resistance in cancer. Increasing evidence shows that glioblastoma (GBM) cells …

Malignant brain tumours are complex ecosystems containing neoplastic and stromal
components that generate adaptive and evolutionarily driven aberrant tissues in the central …

Disseminated tumor cells (DTCs) are known to enter a state of dormancy that is achieved via
growth arrest of DTCs and/or a form of population equilibrium state, strongly influenced by …

Glioblastoma (GBM) remains the most lethal and common primary brain tumor, even after
treatment with multiple therapies, such as surgical resection, chemotherapy, and radiation …

Electron transport chain (ETC) dysfunction or hypoxia causes toxic NADH accumulation.
How cells regenerate NAD+ under such conditions remains elusive. Here, integrating …

Pediatric and adult high-grade gliomas are the most common primary malignant brain
tumors, with poor prognosis due to recurrence and tumor infiltration after therapy. Quiescent …

The communication between glioblastoma stem cells (GSCs) and the surrounding
microenvironment is a prominent feature accounting for the aggressive biology of …

Summary The glycerol-3-phosphate shuttle (G3PS) is a major NADH shuttle that
regenerates reducing equivalents in the cytosol and produces energy in the mitochondria …

Although the role of NOTCH signaling has been extensively studied in health and disease,
many questions still remain unresolved. Being crucial for tissue homeostasis, NOTCH …