Polymeric nanoparticles: production, characterization, toxicology and ecotoxicology

A Zielińska, F Carreiró, AM Oliveira, A Neves, B Pires… - Molecules, 2020 - mdpi.com
Polymeric nanoparticles (NPs) are particles within the size range from 1 to 1000 nm and can
be loaded with active compounds entrapped within or surface-adsorbed onto the polymeric …

Three-dimensional spheroids as in vitro preclinical models for cancer research

B Pinto, AC Henriques, PMA Silva, H Bousbaa - Pharmaceutics, 2020 - mdpi.com
Most cancer biologists still rely on conventional two-dimensional (2D) monolayer culture
techniques to test in vitro anti-tumor drugs prior to in vivo testing. However, the vast majority …

Preparation of solid lipid nanoparticles and nanostructured lipid carriers for drug delivery and the effects of preparation parameters of solvent injection method

VA Duong, TTL Nguyen, HJ Maeng - Molecules, 2020 - mdpi.com
Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) have emerged as
potential drug delivery systems for various applications that are produced from …

SLN and NLC for topical, dermal, and transdermal drug delivery

EB Souto, I Baldim, WP Oliveira, R Rao… - Expert opinion on …, 2020 - Taylor & Francis
Introduction From a biopharmaceutical standpoint, the skin is recognized as an interesting
route for drug delivery. In general, small molecules are able to penetrate the stratum …

[PDF][PDF] Physicochemical and biopharmaceutical aspects influencing skin permeation and role of SLN and NLC for skin drug delivery

EB Souto, JF Fangueiro, AR Fernandes, A Cano… - Heliyon, 2022 - cell.com
The skin is a complex and multifunctional organ, in which the static versus dynamic balance
is responsible for its constant adaptation to variations in the external environment that is …

Applications of natural, semi-synthetic, and synthetic polymers in cosmetic formulations

TFR Alves, M Morsink, F Batain, MV Chaud, T Almeida… - Cosmetics, 2020 - mdpi.com
Cosmetics composed of synthetic and/or semi-synthetic polymers, associated or not with
natural polymers, exhibit a dashing design, with thermal and chemo-sensitive properties …

Nanomaterials for skin delivery of cosmeceuticals and pharmaceuticals

EB Souto, AR Fernandes, C Martins-Gomes… - Applied Sciences, 2020 - mdpi.com
Featured Application The loading of pharmaceuticals and cosmeceuticals into
nanomaterials is discussed as new formulations for potential treatment of age-related skin …

Lipid nanoparticles for the posterior eye segment

L Bonilla, M Espina, P Severino, A Cano, M Ettcheto… - Pharmaceutics, 2021 - mdpi.com
This review highlights the application of lipid nanoparticles (Solid Lipid Nanoparticles,
Nanostructured Lipid Carriers, or Lipid Drug Conjugates) as effective drug carriers for …

Nanopharmaceutics: Part I—Clinical trials legislation and good manufacturing practices (GMP) of nanotherapeutics in the EU

EB Souto, GF Silva, J Dias-Ferreira, A Zielinska… - Pharmaceutics, 2020 - mdpi.com
The latest advances in pharmaceutical technology are leading to the development of cutting
edged approaches to produce what is now known as the “Holy Grail” of medicine …

Sucupira oil-loaded nanostructured lipid carriers (NLC): Lipid screening, factorial design, release profile, and cytotoxicity

R Vieira, P Severino, LA Nalone, SB Souto, AM Silva… - Molecules, 2020 - mdpi.com
Essential oils are odorant liquid oily products consisting of a complex mixture of volatile
compounds obtained from a plant raw material. They have been increasingly proven to act …