In most cases, protein aggregation stems from the establishment of non-native
intermolecular contacts. The formation of insoluble protein aggregates is associated with …

The unique biology of RNA binding proteins is altering our view of the genesis of protein
misfolding diseases. These proteins use aggregation of low complexity domains (LCDs) as …

Aging is characterized by the accumulation of proteins that display amyloid-like behavior.
However, the molecular mechanisms by which these proteins arise remain unclear. Here …

One of the most intriguing fields emerging in current molecular biology is the study of
membraneless organelles formed via liquid–liquid phase separation (LLPS). These …

Protein aggregation is a topic of immense interest to the scientific community due to its role
in several neurodegenerative diseases/disorders and industrial importance. Several in silico …

In nearly all eukaryotes, cellular differentiation is governed by changes in transcription, and
stabilized by chromatin and DNA modification. Gene expression control in the pathogen …

Prions are self‐perpetuating proteins able to switch between a soluble state and an
aggregated‐and‐transmissible conformation. These proteinaceous entities have been …

Prions are a singular subset of proteins able to switch between a soluble conformation and a
self-perpetuating amyloid state. Traditionally associated with neurodegenerative diseases …

Despite major efforts devoted to understanding the phenomenon of prion transmissibility, it
is still poorly understood how this property is encoded in the amino acid sequence. In recent …

Prion-like behaviour is an abrupt process, an “all-or-nothing” transition between a
monomeric species and an “infinite” fibrillated form. Once a nucleation point is formed, the …