Despite advances in uncovering the mechanisms that underlie neuroinflammation and
neurodegenerative disease, therapies that prevent neuronal loss remain elusive. Targeting …

Selective vulnerability of specific brain regions and cell populations is a hallmark of
neurodegenerative disorders. Mechanisms of selective vulnerability involve neuronal …

Mutations in GBA1, encoding glucocerebrosidase (GCase), cause Gaucher disease (GD)
and are also genetic risks in developing Parkinson's disease (PD). Currently, the approved …

The impact of microcystins on the gonad development and reproduction endocrine in the
tadpole stage on amphibians remains unclear. In this study, the tadpoles (Pelophylax …

Parkinson's disease pathology is hypothesized to spread through the brain via axonal
connections between regions and is further modulated by local vulnerabilities within those …

Prion diseases are a special category of brain disorders that have captivated and puzzled
neuroscientists. These diseases are caused by an abnormal isoform of prion protein. Under …

Abstract α-Synuclein, a protein mostly present in presynaptic terminals, accumulates
neuropathologically in Parkinson's disease in a 6-stage sequence and propagates in the …

Despite intense efforts at the bench, the development of successful brain-targeting
therapeutics to relieve malicious neural diseases remains primitive. The brain, being a …

The human brain is the most complicated biological structure on the planet. A major
challenge of brain network modelling lies in its multi-scale spatio-temporal nature, covering …

The complex nature of the human brain, with its intricate organic structure and multiscale
spatio-temporal characteristics ranging from synapses to the entire brain, presents a major …