Simple Summary Extracellular vesicles (EVs) are cell-derived membrane-surrounded
vesicles that carry bioactive molecules and deliver them to recipient cells. Classical EVs are …

Podoplanin is a small cell-surface mucin-like glycoprotein that plays a crucial role in the
development of the alveoli, heart, and lymphatic vascular system. Emerging evidence …

Among mammary tumor-infiltrating immune cells, the highest expression of podoplanin
(PDPN) is found in a subset of tumor-associated macrophages (TAMs). We hereby …

Background Podoplanin (PDPN) is a sialylated membrane glycoprotein that binds to C‐type
lectin‐like receptor 2 on platelets resulting in platelet activation. PDPN is expressed on …

Malignant pleural mesothelioma (MPM) has extremely limited treatment despite a poor
prognosis. Moreover, molecular targeted therapy for MPM has not yet been implemented; …

The tumor immunosuppressive microenvironment (IME) significantly affects tumor
occurrence, progression, and prognosis, but the underlying molecular mechanisms remain …

The heart is imbued with a vast lymphatic network that is responsible for fluid homeostasis
and immune cell trafficking. Disturbances in the forces that regulate microvascular fluid …

During tuberculosis, lung myeloid cells have two opposing roles: they are an intracellular
niche occupied by Mycobacterium tuberculosis, and they restrict bacterial replication. Lung …

Tumour microenvironment determines the fate of treatments. Reconstitution of tumour
conditions is mandatory for alternative in vitro methods devoted to cancer development and …

Activated cancer-associated fibroblasts (CAFs) and fibroblasts that have undergone the
epithelial-mesenchymal transition (EMT) in cancer stroma contribute to tumor progression …