In 1969, McCully made the clinical observation linking elevated plasma homocyst (e) ine
concentrations with vascular disease. 1 He reported autopsy evidence of extensive arterial …

▪ Abstract Homocysteine is a sulfur amino acid whose metabolism stands at the intersection
of two pathways: remethylation to methionine, which requires folate and vitamin B12 (or …

Abstract The enzyme 5, 10-methylenetetrahydrofolate reductase (MTHFR) is involved in
folate metabolism. The MTHFR gene is located on chromosome 1 (1p36. 3), and two …

Folate is a cofactor in one-carbon metabolism, during which it promotes the remethylation of
homocysteine–a cytotoxic sulfur-containing amino acid that can induce DNA strand …

A variant in prothrombin (clotting factor II), a G to A transition at nucleotide position 20210,
has recently been shown to be associated with the prothrombin plasma levels and the risk of …

Metabolic syndrome (MetS) is considered a metabolic disorder that has been steadily
increasing globally and seems to parallel the increasing prevalence of obesity. It consists of …

Purpose: To review epidemiologic studies on the association between homocyst (e) ine
level and risk for cardiovascular disease and the potential benefits of homocysteine …

Background—The results of retrospective and prospective case-control studies have clearly
established that mild elevations of the plasma homocysteine level are associated with …

Context: It has been suggested that elevated total plasma homocysteine levels are
associated with the risk of venous thrombosis. Objective: To assess the relationship of …

Genetic and environmental factors interact in determining the risk of venous
thromboembolism (VTE). The risk associated with the polymorphic variants G1691A of factor …