TRPV4: molecular conductor of a diverse orchestra
Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …
Molecular physiology of TRPV channels: controversies and future challenges
T Rosenbaum, LD Islas - Annual Review of Physiology, 2023 - annualreviews.org
The ability to detect stimuli from the environment plays a pivotal role in our survival. The
molecules that allow the detection of such signals include ion channels, which are proteins …
molecules that allow the detection of such signals include ion channels, which are proteins …
Heat-dependent opening of TRPV1 in the presence of capsaicin
Transient receptor potential vanilloid member 1 (TRPV1) is a Ca2+-permeable cation
channel that serves as the primary heat and capsaicin sensor in humans. Using cryo-EM, we …
channel that serves as the primary heat and capsaicin sensor in humans. Using cryo-EM, we …
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
Transient receptor potential (TRP) channels are sensors for a wide range of cellular and
environmental signals, but elucidating how these channels respond to physical and …
environmental signals, but elucidating how these channels respond to physical and …
Understand spiciness: mechanism of TRPV1 channel activation by capsaicin
Capsaicin in chili peppers bestows the sensation of spiciness. Since the discovery of its
receptor, transient receptor potential vanilloid 1 (TRPV1) ion channel, how capsaicin …
receptor, transient receptor potential vanilloid 1 (TRPV1) ion channel, how capsaicin …
Structural mechanism underlying capsaicin binding and activation of the TRPV1 ion channel
Capsaicin bestows spiciness by activating TRPV1 channel with exquisite potency and
selectivity. Although a capsaicin-bound channel structure was previously resolved by cryo …
selectivity. Although a capsaicin-bound channel structure was previously resolved by cryo …
[HTML][HTML] Epithelia-sensory neuron cross talk underlies cholestatic itch induced by lysophosphatidylcholine
Background & Aims Limited understanding of pruritus mechanisms in cholestatic liver
diseases hinders development of antipruritic treatments. Previous studies implicated …
diseases hinders development of antipruritic treatments. Previous studies implicated …
Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis
Single particle cryo-EM often yields multiple protein conformations within a single dataset,
but experimentally deducing the temporal relationship of these conformers within a …
but experimentally deducing the temporal relationship of these conformers within a …
TRPV1: structure, endogenous agonists, and mechanisms
M Benítez-Angeles, SL Morales-Lázaro… - International journal of …, 2020 - mdpi.com
The Transient Receptor Potential Vanilloid 1 (TRPV1) channel is a polymodal protein with
functions widely linked to the generation of pain. Several agonists of exogenous and …
functions widely linked to the generation of pain. Several agonists of exogenous and …
Modular thermal sensors in temperature-gated transient receptor potential (TRP) channels
J Yao, B Liu, F Qin - … of the National Academy of Sciences, 2011 - National Acad Sciences
The molecular basis of the thermal sensitivity of temperature-sensitive channels appears to
arise from a specific protein domain rather than integration of global thermal effects. Using …
arise from a specific protein domain rather than integration of global thermal effects. Using …