IVIVE: Facilitating the Use of In Vitro Toxicity Data in Risk Assessment and Decision Making
X Chang, YM Tan, DG Allen, S Bell, PC Brown… - Toxics, 2022 - mdpi.com
During the past few decades, the science of toxicology has been undergoing a
transformation from observational to predictive science. New approach methodologies …
transformation from observational to predictive science. New approach methodologies …
Age‐and genotype‐dependent variability in the protein abundance and activity of six major uridine diphosphate‐glucuronosyltransferases in human liver
DK Bhatt, A Mehrotra, A Gaedigk… - Clinical …, 2019 - Wiley Online Library
The ontogeny of hepatic uridine diphosphate‐glucuronosyltransferases (UGTs) was
investigated by determining their protein abundance in human liver microsomes isolated …
investigated by determining their protein abundance in human liver microsomes isolated …
[HTML][HTML] Impaired hepatic vitamin A metabolism in NAFLD mice leading to vitamin A accumulation in hepatocytes
A Saeed, P Bartuzi, J Heegsma, D Dekker… - Cellular and molecular …, 2021 - Elsevier
Background & Aims Systemic retinol (vitamin A) homeostasis is controlled by the liver,
involving close collaboration between hepatocytes and hepatic stellate cells (HSCs) …
involving close collaboration between hepatocytes and hepatic stellate cells (HSCs) …
Aldehyde oxidase and its role as a drug metabolizing enzyme
D Dalvie, L Di - Pharmacology & therapeutics, 2019 - Elsevier
Aldehyde oxidase (AO) is a cytosolic enzyme that belongs to the family of structurally related
molybdoflavoproteins like xanthine oxidase (XO). The enzyme is characterized by broad …
molybdoflavoproteins like xanthine oxidase (XO). The enzyme is characterized by broad …
The role of alcohol dehydrogenase in drug metabolism: beyond ethanol oxidation
L Di, A Balesano, S Jordan, SM Shi - The aaps journal, 2021 - Springer
Alcohol dehydrogenases (ADHs) are most known for their roles in oxidation and elimination
of ethanol. Although less known, ADHs also play a critical role in the metabolism of a …
of ethanol. Although less known, ADHs also play a critical role in the metabolism of a …
Impact of CYP2C:TG Haplotype on CYP2C19 Substrates Clearance In Vivo, Protein Content, and In Vitro Activity
P Zubiaur, P Soria‐Chacartegui… - Clinical …, 2023 - Wiley Online Library
A novel haplotype composed of two non‐coding variants, CYP2C18 NM_000772. 3: c.* 31T
(rs2860840) and NM_000772. 2: c. 819+ 2182G (rs11188059), referred to as “CYP2C: TG,” …
(rs2860840) and NM_000772. 2: c. 819+ 2182G (rs11188059), referred to as “CYP2C: TG,” …
Critical issues and optimized practices in quantification of protein abundance level to determine interindividual variability in DMET proteins by LC‐MS/MS proteomics
Protein quantification data on drug metabolizing enzymes and transporters (collectively
referred as DMET proteins) in human tissues are useful in predicting interindividual …
referred as DMET proteins) in human tissues are useful in predicting interindividual …
Assessment of urinary 6‐oxo‐pipecolic acid as a biomarker for ALDH7A1 deficiency
Y Khalil, E Footitt, R Vootukuri… - Journal of Inherited …, 2024 - Wiley Online Library
ALDH7A1 deficiency is an epileptic encephalopathy whose seizures respond to treatment
with supraphysiological doses of pyridoxine. It arises as a result of damaging variants in …
with supraphysiological doses of pyridoxine. It arises as a result of damaging variants in …
Developmental pharmacokinetics of antibiotics used in neonatal ICU: focus on preterm infants
OI Butranova, EA Ushkalova, SK Zyryanov… - Biomedicines, 2023 - mdpi.com
Neonatal Infections are among the most common reasons for admission to the intensive
care unit. Neonatal sepsis (NS) significantly contributes to mortality rates. Empiric antibiotic …
care unit. Neonatal sepsis (NS) significantly contributes to mortality rates. Empiric antibiotic …