Glia as Functional Barriers and Signaling Intermediaries
VM Fernandes, V Auld… - Cold Spring Harbor …, 2024 - cshperspectives.cshlp.org
Glia play a crucial role in providing metabolic support to neurons across different species. To
do so, glial cells isolate distinct neuronal compartments from systemic signals and …
do so, glial cells isolate distinct neuronal compartments from systemic signals and …
Sarm1-dependent axon degeneration: Nucleotide signaling, neurodegenerative disorders, toxicity, and therapeutic opportunities
Axons are an essential component of the nervous system, and axon degeneration is an
early feature of many neurodegenerative disorders. The NAD+ metabolome plays an …
early feature of many neurodegenerative disorders. The NAD+ metabolome plays an …
Live imaging reveals the cellular events downstream of SARM1 activation
SARM1 is an inducible NAD+ hydrolase that triggers axon loss and neuronal cell death in
the injured and diseased nervous system. While SARM1 activation and enzyme function are …
the injured and diseased nervous system. While SARM1 activation and enzyme function are …
LC3-associated phagocytosis promotes glial degradation of axon debris after injury in Drosophila models
Glial engulfment of neuron-derived debris after trauma, during development, and in
neurodegenerative diseases supports nervous system functions. However, mechanisms …
neurodegenerative diseases supports nervous system functions. However, mechanisms …
Multicore fiber optic imaging reveals that astrocyte calcium activity in the mouse cerebral cortex is modulated by internal motivational state
Astrocytes are a direct target of neuromodulators and can influence neuronal activity on
broad spatial and temporal scales in response to a rise in cytosolic calcium. However, our …
broad spatial and temporal scales in response to a rise in cytosolic calcium. However, our …
SARM1 signaling mechanisms in the injured nervous system
S Sambashivan, MR Freeman - Current opinion in neurobiology, 2021 - Elsevier
Axon degeneration is a prominent feature of the injured nervous system, occurs across
neurological diseases, and drives functional loss in neural circuits. We have seen a …
neurological diseases, and drives functional loss in neural circuits. We have seen a …
Multifaceted roles of SARM1 in axon degeneration and signaling
TJ Waller, CA Collins - Frontiers in Cellular Neuroscience, 2022 - frontiersin.org
Axons are considered to be particularly vulnerable components of the nervous system;
impairments to a neuron's axon leads to an effective silencing of a neuron's ability to …
impairments to a neuron's axon leads to an effective silencing of a neuron's ability to …
Loss of IRF2BPL impairs neuronal maintenance through excess Wnt signaling
De novo truncations in Interferon Regulatory Factor 2 Binding Protein Like (IRF2BPL) lead to
severe childhood-onset neurodegenerative disorders. To determine how loss of IRF2BPL …
severe childhood-onset neurodegenerative disorders. To determine how loss of IRF2BPL …
A critical role for DLK and LZK in axonal repair in the mammalian spinal cord
JM Saikia, CL Chavez-Martinez, ND Kim… - Journal of …, 2022 - Soc Neuroscience
The limited ability for axonal repair after spinal cord injury underlies long-term functional
impairment. Dual leucine-zipper kinase [DLK; MAP kinase kinase kinase 12; MAP3K12] is …
impairment. Dual leucine-zipper kinase [DLK; MAP kinase kinase kinase 12; MAP3K12] is …
Activation of the CaMKII-Sarm1-ASK1-p38 MAP kinase pathway protects against axon degeneration caused by loss of mitochondria
Mitochondrial defects are tightly linked to axon degeneration, yet the underlying cellular
mechanisms remain poorly understood. In Caenorhabditis elegans, PVQ axons that lack …
mechanisms remain poorly understood. In Caenorhabditis elegans, PVQ axons that lack …