Studies of immune system metabolism (" immunometabolism") segregate along two paths.
The first investigates the effects of immune cells on organs that regulate whole-body …

Altered metabolism in cancer cells is pivotal for tumor growth, most notably by providing
energy, reducing equivalents and building blocks while several metabolites exert a …

Enhanced glucose uptake and a switch to glycolysis are key traits of M1 macrophages,
whereas enhanced fatty acid oxidation and oxidative phosphorylation are the main …

A" switch" from oxidative phosphorylation (OXPHOS) to aerobic glycolysis is a hallmark of T
cell activation and is thought to be required to meet the metabolic demands of proliferation …

Classical activation of M1 macrophages with lipopolysaccharide (LPS) is associated with a
metabolic switch from oxidative phosphorylation to glycolysis. However, the generalizability …

The past decade has revealed a new role for the mitochondria in cell metabolism–regulation
of cell death pathways. Considering that most tumor cells are resistant to apoptosis, one …

Proapoptotic proteins such as Bax, undergo translocation to the mitochondria during
apoptosis, where they mediate the release of intermembrane space proteins including …

Despite more than 75 years of research by some of the greatest scientists in the world to
conquer cancer, the clear winner is still cancer. This is reflected particularly by liver cancer …

The last decade has witnessed a renaissance of Otto Warburg's fundamental hypothesis,
which he put forward more than 80years ago, that mitochondrial malfunction and …

Rat liver cytoplasm (postnuclear supernatant) has a low aerobic glycolytic rate in the
presence of added glucose, ATP, ADP, Pi, and NAD+, whereas cytoplasm from Ehrlich …