[HTML][HTML] Metabolic pathways in immune cell activation and quiescence
EL Pearce, EJ Pearce - Immunity, 2013 - cell.com
Studies of immune system metabolism (" immunometabolism") segregate along two paths.
The first investigates the effects of immune cells on organs that regulate whole-body …
The first investigates the effects of immune cells on organs that regulate whole-body …
[HTML][HTML] Cancer metabolism in space and time: beyond the Warburg effect
P Danhier, P Bański, VL Payen, D Grasso… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Altered metabolism in cancer cells is pivotal for tumor growth, most notably by providing
energy, reducing equivalents and building blocks while several metabolites exert a …
energy, reducing equivalents and building blocks while several metabolites exert a …
[HTML][HTML] Glycolytic stimulation is not a requirement for M2 macrophage differentiation
Enhanced glucose uptake and a switch to glycolysis are key traits of M1 macrophages,
whereas enhanced fatty acid oxidation and oxidative phosphorylation are the main …
whereas enhanced fatty acid oxidation and oxidative phosphorylation are the main …
[HTML][HTML] Posttranscriptional control of T cell effector function by aerobic glycolysis
A" switch" from oxidative phosphorylation (OXPHOS) to aerobic glycolysis is a hallmark of T
cell activation and is thought to be required to meet the metabolic demands of proliferation …
cell activation and is thought to be required to meet the metabolic demands of proliferation …
[HTML][HTML] Interferon gamma induces reversible metabolic reprogramming of M1 macrophages to sustain cell viability and pro-inflammatory activity
Classical activation of M1 macrophages with lipopolysaccharide (LPS) is associated with a
metabolic switch from oxidative phosphorylation to glycolysis. However, the generalizability …
metabolic switch from oxidative phosphorylation to glycolysis. However, the generalizability …
Mitochondria in cancer cells: what is so special about them?
V Gogvadze, S Orrenius, B Zhivotovsky - Trends in cell biology, 2008 - cell.com
The past decade has revealed a new role for the mitochondria in cell metabolism–regulation
of cell death pathways. Considering that most tumor cells are resistant to apoptosis, one …
of cell death pathways. Considering that most tumor cells are resistant to apoptosis, one …
[HTML][HTML] Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis
JG Pastorino, N Shulga, JB Hoek - Journal of Biological Chemistry, 2002 - ASBMB
Proapoptotic proteins such as Bax, undergo translocation to the mitochondria during
apoptosis, where they mediate the release of intermembrane space proteins including …
apoptosis, where they mediate the release of intermembrane space proteins including …
[HTML][HTML] Mitochondrial bound type II hexokinase: a key player in the growth and survival of many cancers and an ideal prospect for therapeutic intervention
PL Pedersen, S Mathupala, A Rempel… - … et Biophysica Acta (BBA …, 2002 - Elsevier
Despite more than 75 years of research by some of the greatest scientists in the world to
conquer cancer, the clear winner is still cancer. This is reflected particularly by liver cancer …
conquer cancer, the clear winner is still cancer. This is reflected particularly by liver cancer …
The Warburg effect and mitochondrial stability in cancer cells
V Gogvadze, B Zhivotovsky, S Orrenius - Molecular aspects of medicine, 2010 - Elsevier
The last decade has witnessed a renaissance of Otto Warburg's fundamental hypothesis,
which he put forward more than 80years ago, that mitochondrial malfunction and …
which he put forward more than 80years ago, that mitochondrial malfunction and …
Energy metabolism of tumor cells. Requirement for a form of hexokinase with a propensity for mitochondrial binding.
E Bustamante, HP Morris, PL Pedersen - Journal of Biological Chemistry, 1981 - ASBMB
Rat liver cytoplasm (postnuclear supernatant) has a low aerobic glycolytic rate in the
presence of added glucose, ATP, ADP, Pi, and NAD+, whereas cytoplasm from Ehrlich …
presence of added glucose, ATP, ADP, Pi, and NAD+, whereas cytoplasm from Ehrlich …