Given that genetic differences between individuals or populations can impact the efficacy of
drugs, defining pharmacogenetic differences is regarded as an important factor to consider …

Abstract Background A CYP2D6 gene polymorphism is related to the effect of tamoxifen
treatment in patient with estrogen-receptor positive (ER) positive breast cancer and …

Dihydropyrimidine dehydrogenase (DPYD) is an enzyme that regulates the rate-limiting step
in pyrimidine metabolism, especially catabolism of fluorouracil, a chemotherapeutic agent …

The chemotherapies of FOLFOX (leucovorin+ 5-fluorouracil+ oxaliplatin) and FOLFIRI
(folinic acid+ 5-fluorouracil+ irinotecan) are effective for a variety of malignant tumors. In …

Responses to drugs are influenced by multiple factors, including health status,
environmental influences, and genetic characteristics. The bioavailability of a drug can vary …

Strong K. pneumoniae strains is associated together a bacterial contagion, but is more
susceptible to antimicrobials. K. pneumonia promoting the development of malignant strains …

Cancer is reported to become one of the leading causes of death worldwide. A number of
reasons such as lack of drug efficacy, development of drug resistance and toxicity are …

RESUMO O câncer de mama é classificado mundialmente, como o segundo tipo de câncer
mais frequente e comum entre as mulheres e tem natureza multifatorial. O tratamento …

The present invention provides a TOP2A inhibition by temozolomide useful for predicting
glioblastoma patient's survival. Glioblastoma (GBM) is the most common, malignant primary …