The internalizing spectrum encompasses a subset of psychopathologies characterized by
emotional liability, anhedonia, anxiousness, distress, and fear, and includes, among others …

BackgroundMajor depressive disorder (MDD) is the leading cause of disability globally, with
moderate heritability and well-established socio-environmental risk factors. Genetic studies …

Abstract Treatment resistance is common in major depressive disorder (MDD), yet clinical
risk factors are not well understood. Using a discovery-replication design, we conducted …

Background: Insomnia and substance use disorders (SUD) are common comorbidities of
bipolar disorder (BD). Genome-wide association studies (GWAS) have uncovered shared …

Importance:-There is extensive comorbidity between anxiety disorders (ANX) and major
depression (MD). Most studies on the genetics of ANX do not exclude comorbid cases of …

Аннотация Коморбидность депрессивных и тревожных нарушений—наиболее частая
комбинация психиатрических расстройств, которая связана с более высоким риском …

There is a growing interest in the linkage of cardiovascular health (CVH) with
depression/anxiety but the evidence of “Life's Essential 8” CVH score is scarce. We …

Background Subthreshold anxiety (STA) is a significant risk factor for developing anxiety
disorders (AX), especially during adolescence. Identifying the risk and protective factors in …

Depression is a serious mental disability that is more prone to occur in women than men.
The objective of this study was to assess the effect of saffron on depression in women with …

Background: Mental health syndromes show significant heterogeneity, affecting the
specificity of treatments and research. Past attempts to improve specificity using clustering or …